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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제38권 제3호
- 발행연도
- 2004.1
- 수록면
- 138 - 144 (7page)
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초록· 키워드
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Background : Early hepatocellular carcinoma (HCC) is an early stage HCC, and it is sometimes
difficult to identify the margins of the cancer nodules in the resected specimens. Methods
: We studied 22 cases of early HCC to investigate the clinicopathologic features of early
stage HCC. Results : Seven of 22 cases were single HCC, and 15 were multicentric HCC.
The average tumor size was 1.34 cm (0.4-2.7 cm). Early HCCs didn’t destroy the basic architecture
of the liver lobules or pseudolobules and the lesions had an indistinct margin. Most
tumors were uniformly composed of well-differentiated cancer tissue that was characterized
by an increased cell density and an irregular thin-trabecular pattern. The tumor retained a
varying number of portal tracts. There was a replacing growth pattern at the tumor-nontumor
boundary without tumor capsule. Three of 22 cases had a “nodule-in-nodule” lesion, and the
inner nodules consisted of moderately differentiated HCC without portal tracts. All 22 cases
showed no vascular invasion. All 7 patients with single early HCC have survived for the past
11-54 months without any local recurrence. But in one patient with single early HCC, multicentric
HCC developed 20 months after surgery. Conclusion : The clinicopathologic features
of early HCCs are quite different from those of advanced HCCs. The increased recognition
of early HCC during routine clinical practice will contribute to improved patient survival.
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참고문헌 (20)
참고문헌 신청
Arakawa M / 1986 / Emergence of malignant lesions within an adenomatous hyperplastic nodule in a cirrhotic liver. Observations in five cases. / Gastroenterology 91 : 198 ~ 2
Chen D.S / 1982 / Small hepatocellular carcinoma: a clinicopathological study in thirteen patients / Gastroenterology 83 : 1109 ~ 1119
Edmondson H.A / 1954 / Primary carcinoma of the liver. A study of 100 cases among 48,900 necropsies. / Cancer 7 : 462 ~ 503
Kanai T / 1987 / Pathology of small hepatocellular carcinoma. A proposal for a new gross classification. / Cancer 60 : 810 ~ 819
Kenmochi K / 1987 / Relationship of histologic grade hepatocellular carcinoma (HCC) to tumor size, and demonstration of tumor cells of multiple different grades in single sm
Chen D.S / 1982 / Small hepatocellular carcinoma: a clinicopathological study in thirteen patients / Gastroenterology 83 : 1109 ~ 1119
Edmondson H.A / 1954 / Primary carcinoma of the liver. A study of 100 cases among 48,900 necropsies. / Cancer 7 : 462 ~ 503
Kanai T / 1987 / Pathology of small hepatocellular carcinoma. A proposal for a new gross classification. / Cancer 60 : 810 ~ 819
Kenmochi K / 1987 / Relationship of histologic grade hepatocellular carcinoma (HCC) to tumor size, and demonstration of tumor cells of multiple different grades in single sm
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