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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제43권 제2호
- 발행연도
- 2009.1
- 수록면
- 145 - 151 (7page)
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Background : Nerve growth factor (NGF) has been suggested to participate in tumor progression and it can interact with its receptor p75NGFR. In the present study, we investigated the expressions of NGF and p75NGFR in hepatocellular carcinoma (HCC). Methods : We performed immunohistochemistry for NGF, p75NGFR and PCNA in 45 cases of HCCs, and examined the relationships between the clinicopathologic factors and the immunohistochemical results. Results : NGF was detected in 84.4% (38/45) of the tumor cells and in 64.4% (29/45) of the non-tumorous hepatocytes. Furthermore, a NGF expression was present in 28.9% (13/45) of the endothelial cells in the HCCs, but in 80% (36/45) of the endothelial cells in the non-tumor liver tissue. The tumor cells were negative for p75NGFR in all the HCCs. Although a p75NGFR expression was present in all the nerve fibers in the non-tumor liver tissues, it was markedly reduced (42.2%; 19/45) in the HCCs and a p75NGFR expression was observed at the sinusoids or around the large vessels. The HCCs expressing NGF, either in the tumor cells or the endothelial cells, showed a larger size than those HCCs that didn’t express NGF. The NGF positive tumors showed a tendency toward a higher PCNA-labeling index than did the negative tumors. Conclusions : The changed localization of the NGF expression and the decreased expression of p75NGFR are associated with hepatic carcinogenesis. We suggest that a NGF expression may contribute to the progression of HCC.
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참고문헌 (24)
참고문헌 신청
Bosch FX / 2005 / Epidemiology of hepatocellular carcinoma / Clin Liver Dis 9 : 191 ~ 211
Casaccia-Bonnefil P / 1996 / Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75 / Nature 383 : 716 ~ 719
Cassiman D / 2001 / Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors / Hepatology 33 : 148 ~ 158
Chapman BS / 1995 / A region of the 75 kDa neurotrophin receptor homologous to the death domains of TNFR-I and Fas / FEBS Lett 374 : 216 ~ 220
Descamps S / 1998 / Nerve growth factor is mitogenic for cancerous but not normal human breast epithelial cells / J Biol Chem 273 : 16659 ~ 16662
Casaccia-Bonnefil P / 1996 / Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75 / Nature 383 : 716 ~ 719
Cassiman D / 2001 / Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors / Hepatology 33 : 148 ~ 158
Chapman BS / 1995 / A region of the 75 kDa neurotrophin receptor homologous to the death domains of TNFR-I and Fas / FEBS Lett 374 : 216 ~ 220
Descamps S / 1998 / Nerve growth factor is mitogenic for cancerous but not normal human breast epithelial cells / J Biol Chem 273 : 16659 ~ 16662
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