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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 113 - 126 (14page)
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이 논문의 연구 히스토리 (2)
2013
In vitro and in vivo study of effects of fermented soybean product (chungkookjang) on NGF secretion ability and NGF receptor signaling pathway
Young-Ju Lee
,
Ji-Eun Kim
,
Moon-Hwa Kwak
외 4명
한국실험동물학회 학술발표대회 논문집
2013.08
학술대회자료
In vitro and in vivo study of effects of fermented soybean product (chungkookjang) on NGF secretion ability and NGF receptor signaling pathway
Young-Ju Lee
,
Ji-Eun Kim
,
Moon-Hwa Kwak
외 4명
Laboratory Animal Research
2013.06
학술저널
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초록· 키워드
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In order to investigate the effects of a fermented soybean product (Chungkookjang, CKJ) on nerve growth factor (NGF) metabolism, NGF secretion ability and its related signaling pathway were analyzed in B35 neuronal cells and the Tg2576 mouse model of Alzheimer’s disease (AD). In B35 cells, the concentration of NGF significantly increased upon treatment with Taegwang (TG)-CKJ and Shinhwa (SH)-CKJ extracts compared with vehicle. Further, a significant increase in PC12 cell length as well as the phsophorylation levels of TrkA and Akt, which are members of a high affinity NGF receptor signaling pathway, were observed after treatment with TG-CKJ and SH-CKJ conditional medium (CM). On the other hand, there was no difference in activation of the NGF receptor p75<SUP>NTR</SUP> signaling pathway between vehicle and all CKJ treated groups. In Tg2576 mice showing early stage of AD, the concentrations of NGF in the serum and brain were reduced compared with those in Non-Tg mice. Treatment of Tg2576 mice with SH-CKJ, which contains high concentrations of total flavonoids and phenolic compounds, for 8 weeks dramatically recovered the NGF level to that of Non-Tg mice. Furthermore, the low phosphorylation levels of TrkA and Erk in the NGF receptor TrkA signaling pathway were rapidly recovered to those of Non-Tg mice after SHCKJ treatment in vehicle treated Tg2576 mice, whereas the phosphorylation level of Akt was maintained at a constant level. These results suggest that CKJ may stimulate NGF secretion ability as well as the NGF receptor TrkA signaling pathway in PC12 cells and Tg2576 mice.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (35)
참고문헌 신청
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5. [학술지(정기간행물)] - Priller C / 2006 / Synapse formation and function is modulated by the amyloid precursor protein / J Neurosci 26 (27) : 7212 ~ 7221
2. [학술지(정기간행물)] - Tabert MH / 2005 / A 10-item smell identification scale related to risk for Alzheimer’s disease / Ann Neurol 58 (1) : 155 ~ 160
3. [학술지(정기간행물)] - Tiraboschi P / 2004 / The importance of neuritic plaques and tangles to the development and evolution of AD / Neurology 62 (11) : 1984 ~ 1989
4. [학술지(정기간행물)] - Bouras C / 1994 / Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly patients: a quantitative evaluation of a one-year autopsy population from a geriatric hospital / Cereb Cortex 4 (2) : 138 ~ 150
5. [학술지(정기간행물)] - Priller C / 2006 / Synapse formation and function is modulated by the amyloid precursor protein / J Neurosci 26 (27) : 7212 ~ 7221
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