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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제38권 제5호
- 발행연도
- 2004.1
- 수록면
- 311 - 318 (8page)
이용수
초록· 키워드
오류제보하기
Background : Minocycline, a semisynthetic second-generation tetracycline, is an antibiotic that has excellent ability to penetration into the CNS via the brain-blood barrier. Minocycline has emerged as a potent inhibitor of microglial activation, and it is an effective neuroprotective agent in experimental brain ischemia. Glial cell activation and proliferation are known to be associated with neuropathic pain in the peripheral nerve injuries. Methods : The fifty percent threshold of withdrawal responses was measured in the hindpaws of SD rats following tight ligation of left fifth lumbar spinal nerve. Rats were sacrificed at 1, 3, 5, and 7 days and at 0.5, 1, 2, and 4 h post ligation (n=5/group/time point). Immunohistochemistry for GFAP, CD11b and c-Fos was done on the spinal cord at the level of the fifth lumbar nerve. Minocycline (45 mg/kg) and normal saline (300-400 L) were administered intraperitoneally, 1 day and 1 h before the operations, and every day postoperatively until the rats were sacrificed. Results : Treatment with minocycline reduced allodynia and the expressions of CD11b at 5 days and c-Fos at 1 and 2 h post operation compared with the saline treatment (control). Conclusions : It was thought that minocycline reduced the allodynia induced by tight ligation of the fifth lumbar spinal nerve in rats through the inhibition of microglial activation and c-Fos expression.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
/ / Antisense of c-fos gene attenuates Fosexpression in the spinal cord induced by unilateral constriction ofthe sciatic nerve in the rat : 61 ~ 4
/ / mGlu5 receptor antagonistdecreases Fos expression in spinal neurons after noxious visceralstimulation : 26
/ 1997 / Dissociation of microglial activation and neuropathic pain behaviorsfollowing peripheral nerve injury in the rat. 79 : 163 ~ 175
/ 1998 / Central neuron-glial and glial-glial interactionsfollowing axon injury. 55 : 1 ~ 26
/ 1998 / Central neuron-glial^glial-glial interactionsfollowing axon injury. 55 : 1 ~ 26
/ / mGlu5 receptor antagonistdecreases Fos expression in spinal neurons after noxious visceralstimulation : 26
/ 1997 / Dissociation of microglial activation and neuropathic pain behaviorsfollowing peripheral nerve injury in the rat. 79 : 163 ~ 175
/ 1998 / Central neuron-glial and glial-glial interactionsfollowing axon injury. 55 : 1 ~ 26
/ 1998 / Central neuron-glial^glial-glial interactionsfollowing axon injury. 55 : 1 ~ 26
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초음파 치료가 좌골신경 압좌 손상된 흰쥐의 c-Fos 발현에 미치는 영향
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후계(後谿), 위중(委中), 후계배위중(後谿配委中) 침자(鍼刺)가 백서(白鼠)의 신경병리성(神經病理性) 동통억제(疼痛抑制) 및 c-Fos 단백(蛋白) 발현(發顯)에 미치는 영향(影響)
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