메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Cho, Dong-Charn (Department of Neurosurgery, Hanyang University College of Medicine) Cheong, Jin-Hwan (Department of Neurosurgery, Hanyang University College of Medicine) Yang, Moon-Sul (Department of Neurosurgery, Hanyang University College of Medicine) Hwang, Se-Jin (Department of Anatomy, Hanyang University College of Medicine) Kim, Jae-Min (Department of Neurosurgery, Hanyang University College of Medicine) Kim, Choong-Hyun (Department of Neurosurgery, Hanyang University College of Medicine)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제49권 제2호
발행연도
2011.1
수록면
83 - 91 (9page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Objective : Minocycline, a second-generation tetracycline-class antibiotic, has been well established to exert a neuroprotective effect in animal models and neurodegenerative disease through the inhibition of microglia. Here, we investigated the effects of minocycline on motor recovery and neuropathic pain in a rat model of spinal cord injury. Methods : To simulate spinal cord injury, the rats' spinal cords were hemisected at the 10th thoracic level (T10). Minocycline was injected intraperitoneally, and was administered 30 minutes prior surgery and every second postoperative day until sacrifice 28 days after surgery. Motor recovery was assessed via the Basso-Beattie-Bresnahan test Mechanical hyperalgesia was measured throughout the 28-day post -operative course via the von Frey test Microglial and astrocyte activation was assessed by immunohistochemical staining for ionized calcium binding adaptor molecule 1 (lba1) and glial fibrillary acidic protein (GFAP) at two sites: at the level of hemisection and at the 5th lumbar level (L5). Results : In rats, spinal cord hemisection reduced locomotor function and induced a mechanical hyperalgesia of the ipsilateral hind limb. The expression of lba1 and GFAP was also increased in the dorsal and ventral horns of the spinal cord at the site of hemisection and at the L5 level. Intraperitoneal injection of minocycline facilitated overall motor recovery and attenuated mechanical hyperalgesia. The expression of lba1 and GFAP in the spinal cord was also reduced in rats treated with minocycline. Conclusion : By inhibiting microglia and astrocyte activation, minocycline may facilitate motor recovery and attenuate mechanical hyperalgesia in individuals with spinal cord injuries.
#Spinal cord injury #Minocycline #Astrocyte #Microglia

목차

등록된 정보가 없습니다.

참고문헌 (38)

참고문헌 신청
Amin AR / 1996 / A novel mechanism of action of tetracyclines : effects on nitric oxide synthases / Proc Natl Acad Sci U S A 93:14014~14019 google schola Anthes DL / 1996 / Ultrastructural evidence for arteriolar vasospasm after spinal cord trauma / Neurosurgery 39:804~814 google schola Baptiste DC / 2006 / Pharmacological approaches to repair the injured spinal cord / J Neurotrauma 23:318~334 google schola Basso DC / 1996 / Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection / Exp Neurol 139:244~256 google schola Bracken MB / 1991 / Treatment of acute spinal cord injury with methylprednisolone : results of a multicenter, randomized clinical trial / J Neurotrauma 8:47~52 google schola

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0