지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.3
- 수록면
- 9 - 14 (6page)
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초록· 키워드
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Pulsed radiofrequency (PRF) stimulation into dorsal root ganglion (DRG) has been recently introduced as an alternative method of pain intervention in patients with neuropathic pain. Animal studies further reveal that PRF stimulation into DRG increases Fos expression (neuronal activity marker) in the spinal cord. Thus, it is assumed that PRF induced neuronal activation may be closely related with long-term analgesic effect in the neuropathic conditions. Presently, it is not clear PRF application into peripheral nerve fiber including sciatic nerve also produces analgesic effect in neuropathic pain condition. We firstly evaluated whether PRF application for two minutes into right sciatic nerve of rat in mid thigh increased spinal Fos expression. And then we further investigated whether this PRF application produced analgesic effect on the neuropathy using rat chronic constriction injury (CCI) model. PRF application did not significantly increase Fos expression in the spinal cord as compared with control animals. Furthermore, PRF application failed to reduce the mechanical allodynia and non-noxious stimulation induced spinal Fos expression in CCI model. Therefore, this data suggest that PRF treatment into sciatic nerve do not produce the spinal neuronal activity as well as pain relief in neuropathic animal model.
목차
Materials and Methods
Results
Discussion
References
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