지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제43권 제6호
- 발행연도
- 2009.1
- 수록면
- 528 - 534 (7page)
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초록· 키워드
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Background : KIT and PDGFRA are tyrosine kinase receptors. Stem cell factor/KIT-mediated signaling plays a role in normal spermatogenesis, and the alteration of KIT is important in the pathogenesis of seminomas/dysgerminomas (SD). Methods : To determine the role of
expression and mutation of the KIT and PDGFRA genes, we analyzed 16 seminoma cases, 4 spermatocytic seminoma (SS) cases and 8 dysgerminoma cases for KIT and PDGFRA expression and mutation of KIT (exons 9, 11, 13, and 17) and PDGFRA (exons 12 and 18) using PCR-SSCP methods. Results : KIT was immunohistochemically positive in all 24 SD cases, and one of four (25%) SS cases. PDGFRA was immunohistochemically evident in 16
of the 24 (66.6%) SD cases, and two of the four (50%) SS cases. KIT expression was significantly reduced in SS compared with seminoma (p=0.0035). Four cases (14.3%) displayed mutation in KIT exon 17 or PDGFRA exon 12. Distant metastasis was present in three cases (10.7%), one of which had a nonsense mutation in KIT. Conclusions : These results indicate that KIT is expressed in the majority of SD cases, but not in most SS cases. However, there was no significant correlation between the clinicopathologic features and mutation or expression of KIT and PDGFRA.
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참고문헌 (23)
참고문헌 신청
Antonescu CR / 2003 / Association of KIT exon 9 mutations with nongastric primary site and aggressive behavior:KIT mutation analysis and clinical correlates of 120 gastrointe
Coffey J / 2008 / Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of liter
Do I / 2007 / Protein expression of KIT and gene mutation of c-kit and PDGFRs in Ewing sarcomas / Pathol Res Pract 203 : 127 ~ 134
Heinrich MC / 2002 / Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations / Hum Pathol 33 : 484 ~ 495
Hoei-Hansen CE / 2007 / Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers / Mol Cancer 6 : 12 ~
Coffey J / 2008 / Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of liter
Do I / 2007 / Protein expression of KIT and gene mutation of c-kit and PDGFRs in Ewing sarcomas / Pathol Res Pract 203 : 127 ~ 134
Heinrich MC / 2002 / Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations / Hum Pathol 33 : 484 ~ 495
Hoei-Hansen CE / 2007 / Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers / Mol Cancer 6 : 12 ~
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