Expression of DOG1, CD117 and PDGFRA in Gastrointestinal Stromal Tumors and Correlations with Clinicopathology

Sun, Xiu-Wei; Feng, Zhan-Jun; Huang, Peng; Hao, Wang; Sui, Xing-Ling

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자료유형: 학술저널

저자정보: Sun, Xiu-Wei (Department of Gastroenterology, the Third Affiliated Hospital of Harbin Medical University) Feng, Zhan-Jun (Department of Gastroenterology, the Third Affiliated Hospital of Harbin Medical University) Huang, Peng (Department of Gastroenterology, the Third Affiliated Hospital of Harbin Medical University) Hao, Wang (Department of Gastroenterology, the Third Affiliated Hospital of Harbin Medical University) Sui, Xing-Ling (Department of Gastroenterology, the Third Affiliated Hospital of Harbin Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제4호

발행연도: 2012.1

수록면: 1,389 - 1,393 (5page)

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Objective: To discuss the significance of DOG1, CD117 and PDGFRA in the diagnosis of gastrointestinal stromal tumors (GISTs), and analyze their correlations with clinicopathological features and risk ranking. Method: DOG1, CD117 and PDGFRA were detected with IHC Envision ldpe-g-nvp in 63 GISTs and 43 cases of non-GISTs, and analyzed for relations with clinicopathological factors (gender, age, location, tumor size, mitotic phase, histology) and risk degree. Results: The positive expression rate of DOG1, CD117 and PDGFRA in GISTs was 84.1% (53/63), 90.5% (57/63), 53.2% (33/63), respectively. Among the 6 CD117 negative cases, all were DOG1 positive and 5 were PDGFRA positive. Rates in patients with non-GISTs was 11.6%, 16.3%, 6.98%, respectively. Expression of DOG1 and PDGFRA demonstrated no significant variation with gender, age, position, tumor size, mitotic phase, histology, and risk rank. However, CD117 was related with position and histology (P=0.008 and P=0.045), those in the mesentery having a higher positive rate than those derived from stomach, small intestine, colon and rectum (50.0% vs 94.7%, P=0.008). Furthermore CD117 was also highly expressed in spindle and epithele types. Conclusions: DOG1 had a good sensitivity and specificity as a kind of newly discovered marker, especially for KIT negative GISTs. However, DOG1, CD117 and PDGFRA cannot be used for assessing the rish of patients.

#Gastrointestinal stromal tumor #KIT #PDGFR alpha #clinicopathological features #risk ranking

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