지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 92 - 100 (9page)
이용수
초록· 키워드
오류제보하기
Background: Allergic rhinitis can progress to asthma. Both allergic rhinitis and asthma are characterized by Th2-dependent inflammation due to activated mast cells and eosinophils. Mast cells are dependent on kit-mediated activation, and the stem cell factor (SCF)/c-kit pathway leads to eosinophil infiltration. We investigated whether inflammation through the SCF/c-kit pathway would be associated with upper and lower airway inflammation.
Methods: We enrolled 71 allergic asthma patients with rhinitis (group I) and 47 patients with allergic rhinitis alone (group II), and 59 non-atopic healthy controls (group III). Groups I and II showed positive responses to house dust mites in skin prick tests. The serum concentrations of c-kit receptor and SCF were measured by using ELISA. Eosinophil cationic protein (ECP) levels were measured by using the CAP system. Other clinical parameters were analyzed. Results: There were significant differences in the mean values of c-kit receptor levels between the 3 groups (117.27± 41.05 vs. 93.13±37.21 vs. 88.45±24.32 ng/mL, P＜0.001). The c-kit receptor level was the highest in group I. However, no significant differences were found in SCF levels between the 3 groups. A positive correlation was found between c-kit receptor and ECP levels in groups I and II (r=0.31, P=0.016). Moreover, a positive correlation was found between c-kit receptor levels and total eosinophil counts in groups I and II (r=0.34, P＜0.001). However, there were no significant associations between c-kit receptor levels and clinical parameters, such as forced expiratory volume 1% predicted value in group I.
Conclusion: Serum c-kit receptor levels can be a useful serologic marker for predicting the extent of eosinophilic inflammation in upper and lower airway inflammation.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Al-Muhsen SZ / 2004 / The expression of stem cell factor and c-kit receptor in human asthmatic airways / Clin Exp Allergy 34 : 911 ~ 916
Annesi-Maesano I. / 1999 / Epidemiological evidence of the occurrence of rhinitis and sinusitis in asthmatics / Allergy 54 (57) : 7 ~ 13
Bischoff SC / 1992 / c-kit ligand: a unique potentiator of mediator release by human lung mast cells / J Exp Med 175 : 237 ~ 244
Bousquet J / 2000 / Asthma. From bronchoconstriction to airways inflammation and remodeling / Am J Respir Crit Care Med 161 : 1720 ~ 1745
Bousquet J / 2008 / World Health Organization; GA(2)LEN; AllerGen. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organ
Annesi-Maesano I. / 1999 / Epidemiological evidence of the occurrence of rhinitis and sinusitis in asthmatics / Allergy 54 (57) : 7 ~ 13
Bischoff SC / 1992 / c-kit ligand: a unique potentiator of mediator release by human lung mast cells / J Exp Med 175 : 237 ~ 244
Bousquet J / 2000 / Asthma. From bronchoconstriction to airways inflammation and remodeling / Am J Respir Crit Care Med 161 : 1720 ~ 1745
Bousquet J / 2008 / World Health Organization; GA(2)LEN; AllerGen. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organ
이 논문의 저자 정보
최근 본 자료
댓글(0)
0