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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제41권 제6호
- 발행연도
- 2007.1
- 수록면
- 380 - 386 (7page)
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초록· 키워드
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Background : The aim of this study was to clarify the incidence and role of microsatellite instability
(MSI) in sporadic ovarian epithelial cancers (OEC). We investigated the MSI status and
mismatch repair (MMR) protein expression in OEC. Methods : MSI was examined by fluorescence-
based polymerase chain reaction using five NCI panel markers (BAT25, BAT26, D2S123,
D5S346 and D17S250) in 46 cases of OEC. Immunohistochemistry (IHC) for hMLH1 and
hMSH2 was performed. Results : Seven cases (15.2%) exhibited high-frequency MSI (MSIH),
one exhibited low-frequency MSI (MSI-L), and the remaining 38 demonstrated microsatellite
stability (MSS). MSI-H in OEC was not associated with histologic grade, FIGO stage, tumor
size, mitoses or histologic type. Loss of expression of either hMLH1 or hMSH2 was observed
in 4 of the 7 (59.3%) MSI-H cases, whereas 4 of the 39 (10.3%) MSI-L or MSS tumors revealed
loss of expression of MMR proteins. The sensitivity and specificity of immunohistochemistry
for hMLH1 and hMSH2 were 57.1% and 89.7%. Conclusions : Our data suggest that a genetic
defect in the MMR system might play a role in the carcinogenesis of a minor subset of sporadic
OEC however, immunohistochemical testing for hMLH1 and hMSH2 cannot accurately
determine microsatellite instability status in OEC.
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참고문헌 (25)
참고문헌 신청
[학술지(정기간행물)]
Allen HJ / 2000 / Microsatelliteinstability in ovarian and other pelvic carcinomas 117 : 163 ~ 166
Arzimanoglou II / 1996 / Microsatelliteinstability differences between familial and sporadic ovarian cancers 17 : 1799 ~ 1804
Boland CR / 1998 / A national cancer instituteworkshop on microsatellite instability for cancer detection andfamilial predisposition:Development of international criteria for
Cai KQ / 2004 / Microsatellite instability andalteration of the expression of hMLH1 and hMSH2 in ovarian clearcell carcinoma 35 : 552 ~ 559
Allen HJ / 2000 / Microsatelliteinstability in ovarian and other pelvic carcinomas 117 : 163 ~ 166
Arzimanoglou II / 1996 / Microsatelliteinstability differences between familial and sporadic ovarian cancers 17 : 1799 ~ 1804
Boland CR / 1998 / A national cancer instituteworkshop on microsatellite instability for cancer detection andfamilial predisposition:Development of international criteria for
Cai KQ / 2004 / Microsatellite instability andalteration of the expression of hMLH1 and hMSH2 in ovarian clearcell carcinoma 35 : 552 ~ 559
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