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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 360 - 366 (7page)
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초록· 키워드
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Purpose: The aim of this study was to evaluate the responsiveness to CPT-11 with respect to hMLH1 and hMSH2 protein expressions in primary colorectal tumors. Material and Methods: 91 patients with colorectal cancer treated having undergone surgery and postoperative CPT-11-based adjuvant chemotherapy, between 1997 and 2002, were prospectively recruited. Tumor samples were immunohistochemically analyzed for the expressions of hMLH1, hMSH2, p53 and CEA proteins. Results: Of the 91 tumors, 6 (6.6%) and 4 (4.4%) showed loss of hMLH1 and hMSH2 protein expressions, respectively. The response rate of patients with tumors not expressing either hMLH1 or hMSH2 was higher than that of those expressing either of these proteins (p=0.026). Patients with tumors not expressing hMLH1 showed a significantly better response to CPT-11 (p=0.04). The responsiveness was not associated with the expressions of hMSH2, p53 or CEA. There were no correlations between drug toxicity and the expressions of hMLH1, hMSH2 or p53. The overall survival was better in patients responsive to CPT-11-based chemotherapy compared to non-responders. Conclusion: The immunohistochemical determination of loss of hMLH1 and hMSH2 expressions may be used in determining the responsiveness to CPT-11-based chemotherapy. Our results suggest that hMLH1 protein expression may be a predictor for CPT-11 responsiveness in patients with colorectal cancer. (Cancer Res Treat. 2004;36:360-366)
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참고문헌 (24)
참고문헌 신청
/ / Microsatellite instability and the clinicopathological
/ 1979 / WHO handbook for reporting results of cancer treatment : 48 ~
/ 1993 / Defective mismatchbinding and a mutator phenotype in cells tolerant toDNA damage 15 : 652 ~ 4
/ 1993 / Estimates of the worldwidemortality from eighteen major cancers in 1985 Implicationsfor prevention and projections of future burden : 891 ~ 903
/ 1993 / The chemotherapy of colon cancercan no longer be ignored 29a : 2077 ~ 9
/ 1979 / WHO handbook for reporting results of cancer treatment : 48 ~
/ 1993 / Defective mismatchbinding and a mutator phenotype in cells tolerant toDNA damage 15 : 652 ~ 4
/ 1993 / Estimates of the worldwidemortality from eighteen major cancers in 1985 Implicationsfor prevention and projections of future burden : 891 ~ 903
/ 1993 / The chemotherapy of colon cancercan no longer be ignored 29a : 2077 ~ 9
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