지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 227 - 236 (10page)
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초록· 키워드
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Ulcerative colitis (UC) is a serious gastrointestinal tract disease characterized by recurrent chronic inflammation and mucosal damage of the gastrointestinal tract. The conventional therapies of choice are anti-inflammatory agents, steroids and anti-TNF-α therapy. However, inherent limitations in these therapies have steered many UC patients to supplement existing therapies with alternative medicinal products. In the current study, we tested the efficacy of Gingko bilola extract (EGb 761) in abating colonic inflammation in a DSS-induced murine model of colitis. C57BL/6 mice were administered 2% DSS in the drinking water for 7 days, then regular water for 7 days, and then 2% DSS for an additional 7 days. EGb 761 (1 mg/dose) was oral gavaged daily for the duration of the experiment. At the termination of the experiment, mice treated with EGb+DSS showed higher body weight, lower spleen weight and longer colon length compared to mice treated with DSS alone. HE-stained colon tissues also exhibited less histologic inflammation in mice treated with EGb+ DSS mice compared to mice treated with DSS alone. The serum levels inflammatory cytokines, KC and TNF-α, were also decreased in mice treated with EGb+DSS compared to mice treated with DSS alone. Finally, addition of EGb 761 to TNF-α treated colonic cell line (HT29/c1) decreased secretion of IL-8 in vitro. These results collectively suggest that EGb 761 abates induction of colitis in DSS-induced model of colitis in mice.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (43)
참고문헌 신청
1. [학술지(정기간행물)] - Buhner S / 2006 / Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation? / Gut 55 : 342 ~ 347
2. [학술지(정기간행물)] - Cheng SM / 2003 / Down-regulation of c-jun N-terminal kinaseactivator protein-1 signaling pathway by Ginkgo biloba extract in human peripheral blood T cells / Biochem Pharmacol 66 : 679 ~ 689
3. [학술지(정기간행물)] - DeFeudis FV / 2000 / Ginkgo biloba extract (EGb 761) and CNS functions: basic studies and clinical applications / Curr Drug Targets : 25 ~ 58
4. [학술지(정기간행물)] - Gertz HJ / 2004 / Review about Ginkgo biloba special extract EGb 761 (Ginkgo) / Curr Pharm Des 10 : 261 ~ 264
5. [학술지(정기간행물)] - Hanauer SB / 2006 / Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities / Inflamm Bowel Dis 12 (Suppl 1) : S3 ~ S9
2. [학술지(정기간행물)] - Cheng SM / 2003 / Down-regulation of c-jun N-terminal kinaseactivator protein-1 signaling pathway by Ginkgo biloba extract in human peripheral blood T cells / Biochem Pharmacol 66 : 679 ~ 689
3. [학술지(정기간행물)] - DeFeudis FV / 2000 / Ginkgo biloba extract (EGb 761) and CNS functions: basic studies and clinical applications / Curr Drug Targets : 25 ~ 58
4. [학술지(정기간행물)] - Gertz HJ / 2004 / Review about Ginkgo biloba special extract EGb 761 (Ginkgo) / Curr Pharm Des 10 : 261 ~ 264
5. [학술지(정기간행물)] - Hanauer SB / 2006 / Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities / Inflamm Bowel Dis 12 (Suppl 1) : S3 ~ S9
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UCI(KEPA) : I410-ECN-0101-2016-510-001024237