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논문 기본 정보

자료유형
학술저널
저자정보
Park, Jae-Woo (Department of Gastroenterology, College of Oriental Medicine, Kyung Hee University) Bu, Young-Min (Department of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) Bae, Jin-Hyun (Department of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) Lee, Beom-Joon (Department of Internal Medicine, Kangnam Oriental Hospital, Kyung Hee University) Ko, Seok-Jae (Department of Gastroenterology, College of Oriental Medicine, Kyung Hee University) Kim, Jin-Sung (Department of Gastroenterology, College of Oriental Medicine, Kyung Hee University) Ryu, Bong-Ha (Department of Gastroenterology, College of Oriental Medicine, Kyung Hee University)
저널정보
경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제11권 제2호
발행연도
2011.1
수록면
107 - 112 (6page)

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In traditional Korean medicine, $Ulmus$ $macrocarpa$ Hance is a frequently used herb in South Korea for treating intestinal disorders such as colitis. This study investigated whether water extract of $Ulmus$ $macrocarpa$ Hance (UME) could show a protective action on 2 different mice models of experimental colitis induced by dextran sulfate sodium (DSS) and 2,4,6-trinitrobenzenesulfonic acid (TNBS), which have been widely used as inflammatory bowel disease models. Colitis was induced by DSS and TNBS in balb/c mice, respectively. UME at doses of 100, 300, or 1000 mg/kg was orally administered twice a day for 7 d in the DSS model and at doses of 300 or 1000 mg/kg for 3 d in the TNBS model. The body weight of the mice and clinical score were measured daily. Colon length and macroscopic score were assessed on day 7 in the DSS model and on day 3 in the TNBS model. In the DSS model, UME inhibited shortening of colon length and macroscopic damages of the colon, and showed improvement of clinical score, however it did not inhibit weight loss. In the TNBS model, UME did not inhibit weight loss and shortening of colon length. The current results indicate that UME ameliorates DSS-induced colitis in mice similar to human ulcerative colitis, not TNBS-induced colitis in mice similar to human Crohn's disease. Further investigations to unveil the exact mechanisms are needed.

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