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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제43권 제5호
- 발행연도
- 2009.1
- 수록면
- 435 - 440 (6page)
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초록· 키워드
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Background : Taxane-platinum combinations are often used as first-line treatments for patients with advanced non-small cell lung cancer (NSCLC). Response to chemotherapy for these patients is still poor. The aim of our study was to investigate, for this disease, whether KRAS and Tau proteins affect responses to taxane-platinum combinations. Methods : Expression of KRAS and Tau was examined immunohistochemically in 71 tumor samples obtained from patients with stage ⅢB or Ⅳ NSCLC prior to combination therapy. Expression was correlated with tumor responses. Results : The response rate was 55% (39 of 71). KRAS and Tau were expressed in seven (10%) and 31 (44%) patients, respectively. All seven KRAS-positive patients were non-responders (p=0.014). Among Tau-positive patients , 35% (11 of 31) responded to therapy, whereas a partial response was observed in 70% (28 of 40) of Tau-negatives (p= 0.045). Two were positive for both, and they were non-responders. In patients negative for both, the response rate was 71% (25 of 35) (p=0.012). Conclusions : Expression of KRAS and Tau are significantly correlated with poor responses to this combination therapy in advanced NSCLC patients, and may be a useful marker for chemoresistance.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Chu Q / 2005 / Taxanes as firstline therapy for advanced non-small cell lung cancer: a systematic review and practice guideline / Lung Cancer 50 : 355 ~ 374
Cvetkovic G / 2009 / K-ras mutation predictive significance in platinum based chemotherapeutic protocols in patients with advanced non-small cell lung cancer / Vojnosanit Pr
Dumontet C / 2005 / Expression of class III beta tubulin in non-small cell lung cancer is correlated with re
Guha U / 2008 / Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS / Proc Natl Acad Sci : 14112 ~ 14117
Harada M / 1992 / Prognostic significance of the expression of ras oncogene product in non-small cell lung cancer / Cancer 69 : 72 ~ 77
Cvetkovic G / 2009 / K-ras mutation predictive significance in platinum based chemotherapeutic protocols in patients with advanced non-small cell lung cancer / Vojnosanit Pr
Dumontet C / 2005 / Expression of class III beta tubulin in non-small cell lung cancer is correlated with re
Guha U / 2008 / Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS / Proc Natl Acad Sci : 14112 ~ 14117
Harada M / 1992 / Prognostic significance of the expression of ras oncogene product in non-small cell lung cancer / Cancer 69 : 72 ~ 77
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