지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Fetal DNA (fDNA) detection in maternal serum is a challenge due to low copy number and the smaller size of fDNA fragments compared to DNA fragments derived from the mother. Massively parallel sequencing (MPS) is a useful technique for fetal genetic analysis that is able to detect and quantify small amounts of DNA. In this study, seven clinical samples of maternal serum potentially containing fDNA were analyzed with a commercial single nucleotide polymorphism (SNP) panel, the HID-Ion AmpliSeqTM Identity Panel, and the results were compared to those from previous studies. Reference profiles for mothers and fetuses were not available, but multiple Y chromosomal SNPs were detected in two samples, indicating that fDNA was present in the serum and thereby validating observations of autosomal SNPs. This suggests that SNP-based MPS can be valuable for fDNA detection, thereby offering an insight into fetal genetic status. This technology could also be used to detect small amounts of DNA in mixed DNA samples for forensic applications.
목차
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참고문헌 (10)
참고문헌 신청
Barra GB / 2015 / Fetal male lineage determination by analysis of Y-chromosome STR haplotype in maternal plasma / Forensic Sci Int Genet 15 : 105 ~ 110
Borsting C / 2014 / Evaluation of the Ion Torrent™ HID SNP 169-plex: A SNP typing assay developed for human identification by second generation sequencing / Forensic Sci Int
Buchard A / 2016 / ISO 17025 validation of a next-generation sequencing assay for relationship testing / Electrophoresis 37 : 2822 ~ 2831
Chan KC / 2004 / Size distributions of maternal and fetal DNA in maternal plasma / Clin Chem 50 : 88 ~ 92
Chitty LS / 2015 / Non-invasive prenatal diagnosis of achondroplasia and thanatophoric dysplasia: nextgeneration sequencing allows for a safer, more accurate, and comprehensi
Borsting C / 2014 / Evaluation of the Ion Torrent™ HID SNP 169-plex: A SNP typing assay developed for human identification by second generation sequencing / Forensic Sci Int
Buchard A / 2016 / ISO 17025 validation of a next-generation sequencing assay for relationship testing / Electrophoresis 37 : 2822 ~ 2831
Chan KC / 2004 / Size distributions of maternal and fetal DNA in maternal plasma / Clin Chem 50 : 88 ~ 92
Chitty LS / 2015 / Non-invasive prenatal diagnosis of achondroplasia and thanatophoric dysplasia: nextgeneration sequencing allows for a safer, more accurate, and comprehensi
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