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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 155 - 161 (7page)
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초록· 키워드
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Dental pulp is a highly vascularized tissue with high regenerative potential. Revascularization of severed vasculature in the tooth is required for pulp healing during avulsed tooth treatment. In this study, the relative expression of angiogenesis-related proteins was determined in human dental pulp cells using a human angiogenesis proteome profiler array. The proteome profiler array detected differentially expressed angiogenesis-related factors under conditions of hypoxia, which enhances the angiogenic potential of dental pulp cells. We confirmed that hypoxia regulates the mRNA expression of angiogenesis-related factors, including CXCL16 in dental pulp cells. Furthermore, conditioned media of hypoxic pulp cells induced tube-like structures of vascular endothelial cells, which were reduced by the neutralization of CXCL16 function. In conclusion, our data show that angiogenesisrelated factors are differentially expressed by hypoxia in dental pulp cells and suggest that CXCL16 may involve in the revascularization of hypoxic dental pulp.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Abd-Elmeguid A / 2009 / Dental pulp neurophysiology: Part 1. clinical and diagnostic implications / J Can Dent Assoc 75:55~59
Yoon-Kyu Park / 2012 / A Trial of Screening of Genes Involved in Odontoblasts Differentiation from Human Dental Pulp Stem Cells / International Journal of Oral Biology 37(4):167~173
M. Nakashima / 2011 / Regeneration of Dental Pulp by Stem Cells / Advances in Dental Research 23(3):313~319
L. Tran-Hung / 2006 / Role of Human Pulp Fibroblasts in Angiogenesis / Journal of Dental Research 85(9):819~823
Peter Carmeliet / 2000 / Angiogenesis in cancer and other diseases / Nature 407(6801):249~257
Yoon-Kyu Park / 2012 / A Trial of Screening of Genes Involved in Odontoblasts Differentiation from Human Dental Pulp Stem Cells / International Journal of Oral Biology 37(4):167~173
M. Nakashima / 2011 / Regeneration of Dental Pulp by Stem Cells / Advances in Dental Research 23(3):313~319
L. Tran-Hung / 2006 / Role of Human Pulp Fibroblasts in Angiogenesis / Journal of Dental Research 85(9):819~823
Peter Carmeliet / 2000 / Angiogenesis in cancer and other diseases / Nature 407(6801):249~257
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