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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 215 - 220 (6page)
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Angelica decursiva has been used in Korean traditional medicine as an antitussive, an analgesic, an antipyretic and a cough remedy. However, its anti-cancer properties have not yet been well defined. In our current study, we report the cytotoxic activity and the mechanism of cell death induced by ethanol extracts of Angelica decursiva (EEAD) against the human oral cancer cell line, KB. Treatment of KB cells with EEAD induced apoptotic cell death in both a dose- and time-dependent manner as determined by MTT assay and DNA fragmentation. However, no cytotoxic effects of EEAD against human normal oral keratinocytes (HNOK) were evident. By western blot analysis, we found that apoptosis in KB cells is associated with a decrease in procaspase-7 and -9.
In addition, the activation of caspase-7 was detectable in living KB cells by fluorescence microscopy. These results suggest that EEAD exhibits anti-cancer activity in KB cells via apoptosis and thus has potential as an anticancer agent in future drug development strategies.
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참고문헌 (28)
참고문헌 신청
Cheng YS / 2005 / Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo / Cancer Lett 222 : 183 ~ 193
Chicca A / 2007 / Cytotoxic effects of Echinacea root hehanic extracts on human cancer lines / J Ethnopharmacol 110 : 148 ~ 153
Christou L / 2001 / Treatment of plasma cell leukemia with vincristine, liposomal doxorubicin and dexamethasone / Eur J Haematol 67 : 51 ~ 53
Cohen GM / 1997 / Caspases: the executioners of apoptosis / Biochem J 326 : 1 ~ 16
Datta R / 1997 / Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis / J Biol Chem 272 : 20317 ~ 20320
Chicca A / 2007 / Cytotoxic effects of Echinacea root hehanic extracts on human cancer lines / J Ethnopharmacol 110 : 148 ~ 153
Christou L / 2001 / Treatment of plasma cell leukemia with vincristine, liposomal doxorubicin and dexamethasone / Eur J Haematol 67 : 51 ~ 53
Cohen GM / 1997 / Caspases: the executioners of apoptosis / Biochem J 326 : 1 ~ 16
Datta R / 1997 / Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis / J Biol Chem 272 : 20317 ~ 20320
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