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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 39 - 46 (8page)
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Psoralea corylifolia is widely distributed over southeastern Asian countries and has been used in traditional Chinese medicine. Bavachin, one of the main constituents of P. corylifolia, possesses various biological activities such as inhibition of platelet aggregation, anti-oxidation, and anti-bacterial activity. However, the anti-cancer activity of bavachin has not yet been well defined. In this study, the cytotoxic activity of bavachin and its mechanism of cell death were examined in KB human oral cancer cells. Treatment of KB cells with bavachin cells induced inhibition of cell growth in a concentration- and a time-dependent manner as determined by MTT assay. Treatment with bavachin induced nuclear condensation and DNA fragmentation in KB cells. Proteolytic processing of caspases-3, -7, -8, and -9 was elevated by bavachin treatment in KB cells. These results suggest that bavachin can induce suppression of cell growth and cell apoptosis in KB human oral cancer cells, and thus it may have potential effects for anti-cancer drug discovery.
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참고문헌 (27)
참고문헌 신청
Chen X / 2013 / Isobavachalcone and bavachinin from Psoraleae Fructus modulate A 42 aggregation process through different mechanisms in vitro / FEBS Lett 587 : 2930 ~ 2935
Cheng CC / 2010 / Phytoestrogen bavachin mediates anti-inflammation targeting Ikappa B kinase-I kappaB alpha-NF-kappaB signaling pathway in chondrocytes in vitro / Eur J Pha
Cheng YL / 2005 / Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo / Cancer Lett 222 : 183 ~ 193
Christou L / 2001 / Treatment of plasma cell leukemia with vincristine, liposomal doxorubicin and dexamethasone / Eur J Haematol 67 : 51 ~ 53
Cohen GM / 1997 / Caspases: the executioners of apoptosis / Biochem J 326 : 1 ~ 16
Cheng CC / 2010 / Phytoestrogen bavachin mediates anti-inflammation targeting Ikappa B kinase-I kappaB alpha-NF-kappaB signaling pathway in chondrocytes in vitro / Eur J Pha
Cheng YL / 2005 / Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo / Cancer Lett 222 : 183 ~ 193
Christou L / 2001 / Treatment of plasma cell leukemia with vincristine, liposomal doxorubicin and dexamethasone / Eur J Haematol 67 : 51 ~ 53
Cohen GM / 1997 / Caspases: the executioners of apoptosis / Biochem J 326 : 1 ~ 16
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