지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 167 - 175 (9page)
이용수
초록· 키워드
오류제보하기
Chemotherapy has long been considered as one of useful strategies for cancer treatment. It is primarily based on the apoptosis that can selectively kill cancer cells. However, cancer cells can progressively develop an acquired resistance to apoptotic cell death, rendering refractory to chemo- and radiotherapies. Although the mechanism by which cells attained resistance to drug remains to be clarified, it might be caused by either pumping out of them or interfering with apoptotic signal cascades in response to cancer drugs. In case that cancer cells are defective in some part of apoptotic machinery by repeated exposure to anticancer drugs, alternative cell death mechanistically distinct from apoptosis could be adopted to remove cancer cells refractory to apoptosis-inducing agents. This review will mainly deal with harnessing of necrotic cell death, specifically, programmed necrosis and practical uses. Here, we begin with various defects of apoptotic death machinery in cancer cells, and then provide new perspective on programmed necrosis as an alternative anticancer approach.
목차
등록된 정보가 없습니다.
참고문헌 (80)
참고문헌 신청
Amaravadi, R. K / 2007 / The roles of therapyinducedautophagy and necrosis in cancer treatment / Clin. CancerRes 13:7271~7279
Bai, X / 2003 / Honokiol, a smallmolecular weight natural product, inhibits angiogenesis in vitro andtumor growth in vivo / J. Biol. Chem 278:35501~35507
Basu, A / 1998 / The relationship between BcI2, Baxand p53: consequences for cell cycle progression and cell death / Mol. Hum. Reprod 4:1099~1109
Bown, S. G / 2002 / Photodynamic therapy for cancer of the pancreas / Gut 50:549~557
Boya, P / 2005 / Inhibition ofmacroautophagy triggers apoptosis / Mol. Cell. Biol 25:1025~1040
Bai, X / 2003 / Honokiol, a smallmolecular weight natural product, inhibits angiogenesis in vitro andtumor growth in vivo / J. Biol. Chem 278:35501~35507
Basu, A / 1998 / The relationship between BcI2, Baxand p53: consequences for cell cycle progression and cell death / Mol. Hum. Reprod 4:1099~1109
Bown, S. G / 2002 / Photodynamic therapy for cancer of the pancreas / Gut 50:549~557
Boya, P / 2005 / Inhibition ofmacroautophagy triggers apoptosis / Mol. Cell. Biol 25:1025~1040
이 논문의 저자 정보
최근 본 자료
댓글(0)
0