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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 343 - 348 (6page)
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GATA4 has been reported to act as a negative regulator in osteoblast differentiation by inhibiting the Dlx5 transactivation of Runx2 via the attenuation of the binding ability of Dlx5 to the Runx2 promoter region. Here, we determine the role of GATA4 in the regulation of bone sialoprotein (Bsp) in osteoblasts. We observed that the overexpression of Runx2 or Sox9 induced the Bsp expression in osteoblastic cells.
Silencing GATA4 further enhanced the Runx2- and Sox9- mediated Bsp promoter activity, whereas GATA4 overexpression down-regulated Bsp promoter activity mediated by Runx2 and Sox9. GATA4 also interacted with Runx2 and Sox9, by attenuating the binding ability of Runx2 and Sox9 to the Bsp promoter region. Our data suggest that GATA4 acts as a negative regulator of Bsp expression in osteoblasts.
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참고문헌 (24)
참고문헌 신청
김정하 / 2016 / Signaling Pathways in Osteoclast Differentiation / 전남의대학술지 52(1):12~17
Walsh MC / 2006 / Osteoimmunology : interplay between the immune system, bone metabolism / Annu Rev Immunol 24:33~63
Komori T / 1997 / Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts / Cell 89:755~764
Otto F / 1997 / Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation, bone development / Cell 89:765~771
Lee B / 1997 / Missense mutations abolishing DNA binding of the osteoblastspecific transcription factor OSF2/CBFA1 in cleidocranial dysplasia / Nat Genet 16:307~310
Walsh MC / 2006 / Osteoimmunology : interplay between the immune system, bone metabolism / Annu Rev Immunol 24:33~63
Komori T / 1997 / Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts / Cell 89:755~764
Otto F / 1997 / Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation, bone development / Cell 89:765~771
Lee B / 1997 / Missense mutations abolishing DNA binding of the osteoblastspecific transcription factor OSF2/CBFA1 in cleidocranial dysplasia / Nat Genet 16:307~310
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