지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.8
- 수록면
- 1 - 7 (7page)
- DOI
- 10.1038/s12276-020-0471-4
이용수
초록· 키워드
오류제보하기
RUNX2 is a master transcription factor of osteoblast differentiation. RUNX2 expression in the bone and osteogenic front of a suture is crucial for cranial suture closure and membranous bone morphogenesis. In this manner, the regulation of RUNX2 is precisely controlled by multiple posttranslational modi?cations (PTMs) mediated by the stepwise recruitment of multiple enzymes. Genetic defects in RUNX2 itself or in its PTM regulatory pathways result in craniofacial malformations. Haploinsuf?ciency in RUNX2 causes cleidocranial dysplasia (CCD), which is characterized by open fontanelle and hypoplastic clavicles. In contrast, gain-of-function mutations in FGFRs, which are known upstream stimulating signals of RUNX2 activity, cause craniosynostosis (CS) characterized by premature suture obliteration. The identi?cation of these PTM cascades could suggest suitable drug targets for RUNX2 regulation. In this review, we will focus on the mechanism of RUNX2 regulation mediated by PTMs, such as phosphorylation, prolyl isomerization, acetylation, and ubiquitination, and we will summarize the therapeutics associated with each PTM enzyme for the treatment of congenital cranial suture anomalies.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Epigenetic silencing of UBXN8 contributes to leukemogenesis in t(8;21) acute myeloid leukemia
Experimental and Molecular Medicine
2021 .12
-
Inhibition of miR338 rescues cleidocranial dysplasia in Runx2 mutant mice partially via the Hif1a-Vegfa axis
Experimental and Molecular Medicine
2023 .01
-
GATA4 negatively regulates bone sialoprotein expression in osteoblasts
BMB Reports
2016 .01
-
Emerging role of RUNX3 in the regulation of tumor microenvironment
BMB Reports
2018 .01
-
Healing of Tibial and Calvarial Bone Defect using Runx-2-transfected Adipose Stem Cells
조직공학과 재생의학
2015 .01
-
Inducing Osteogenic Differentiation of Human Mesenchymal Stem Cell Using 30Kc19α-Runx2 Protein
한국생물공학회 학술대회
2017 .10
-
Enhanced Osteogenesis of Human Mesenchymal Stem Cell by Intracellular Delivery of Runx2 Protein
한국생물공학회 학술대회
2018 .10
-
Induction of Mesenchymal Stem Cell Differentiation into Osteoblasts by 30Kc19α-Runx2 Fusion Protein
한국생물공학회 학술대회
2018 .04
-
Analyzing Model Hubs for Effective Composition of Pre-Trained Machine Learning Models
Journal of KIISE
2025 .01
-
Identifying Post-translational Modification Crosstalks for Breast Cancer
Journal of Computing Science and Engineering
2017 .12
-
Extracellular Vesicles Carrying RUNX3 Promote Differentiation of Dental Pulp Stem Cells
조직공학과 재생의학
2024 .01
-
In Vitro Osteogenesis of Human Mesenchymal Stem Cell by Recombinant 30Kc19α-Runx2 Protein
한국생물공학회 학술대회
2019 .04
-
토양 숙련도 시험용 금속 표준시료(PTMs) 제조방법 확립 및 적용성 평가
환경분석과 독성보건
2016 .01
-
SC-PTM 서비스를 하는 이웃한 셀간 효율적인 협력 방안
한국통신학회 학술대회논문집
2016 .06
-
Enhanced Bone Affinity of 30Kc19α-RUNX2 Using Hydroxyapatite Binding Tag
한국생물공학회 학술대회
2022 .09
-
Osteogenic Induction Capability of Runx2-Conjugated 30kc19α in Mesenchymal Stem Cells
한국생물공학회 학술대회
2019 .10
-
RBM24 exacerbates bladder cancer progression by forming a Runx1t1/TCF4/miR-625-5p feedback loop
Experimental and Molecular Medicine
2021 .05
-
0가 금속 전구체를 통해 합성된 고결정성 흑연 지지체에 대한 PtM 촉매의 향상된 탄소 부식 저항성 및 산소 환원 반응 성능
한국에너지학회 학술발표회
2023 .10
-
Participation of GATA-3 in regulation of bone healing through transcriptional upregulation of bcl-xL expression
Experimental and Molecular Medicine
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0