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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 738 - 743 (6page)
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초록· 키워드
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The c-Jun NH2-terminal kinase (JNK) signaling pathway participates in many physiological functions. In the current study we reported the cloning and characterization of five novel JNK2transcript variants, which were designated as JNK2α3, JNK2α4,JNK2β3, JNK2γ1 and JNK2γ2, respectively. Among them,JNK2α4 and JNK2γ2 are potential non-coding RNA because they contain pre-mature stop codons. Both JNK2α3 and JNK2β3contain an intact kinase domain, and both encode a protein product of 46 kDa, the same as those of JNK2α1 and JNK2β1.
JNK2γ1 contains a disrupted kinase domain and it showed a disable function. When over-expressed in mammalian cells,JNK2α3 showed higher activity on AP-1 than that of JNK2β3and JNK2γ1. Furthermore, JNK2α3 and JNK2β3 showed different levels of substrate phosphorylation, although they both could promote the proliferation of 293T cells. Our results further demonstrate that JNK2 isoforms preferentially target different substrates and may regulate the expression of various target genes.
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참고문헌 (20)
참고문헌 신청
Bode, A. M. / 2007 / The functional contrariety of JNK / Mol. Carcinog. 46 : 591 ~ 598
Cui, J. / 2005 / Identification of a specific domain responsible for JNK2alpha2 autophosphorylation / J. Biol. Chem. 280 : 9913 ~ 9920
Davis, R. J. / 2000 / Signal transduction by the JNK group of MAP kinases / Cell 103 : 239 ~ 252
Dhanasekaran, D. N. / 2008 / JNK signaling in apoptosis / Oncogene 27 : 6245 ~ 6251
Dreskin, S. C. / 2001 / Isoforms of Jun kinase are differentially expressed and activated in human monocyte/macrophage (THP-1) cells / J. Immunol. 166 : 5646 ~ 5653
Cui, J. / 2005 / Identification of a specific domain responsible for JNK2alpha2 autophosphorylation / J. Biol. Chem. 280 : 9913 ~ 9920
Davis, R. J. / 2000 / Signal transduction by the JNK group of MAP kinases / Cell 103 : 239 ~ 252
Dhanasekaran, D. N. / 2008 / JNK signaling in apoptosis / Oncogene 27 : 6245 ~ 6251
Dreskin, S. C. / 2001 / Isoforms of Jun kinase are differentially expressed and activated in human monocyte/macrophage (THP-1) cells / J. Immunol. 166 : 5646 ~ 5653
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