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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 583 - 588 (6page)
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Leukotactin(Lkn)-1 is a CC chemokine and is upregulated in macrophages in response to Mycobacterium tuberculosis (MTB)infection. We investigated whether mitogen-activated protein kinases (MAPKs) are involved in MTB-induced expression of Lkn-1. The up-regulation of Lkn-1 by infection with MTB was inhibited in cells treated with inhibitors specific for JNK (SP600125) or p38 MAPK (SB202190). Since the up-regulation of Lkn-1 by MTB has been reported to be mediated by the PI3-K/PDK1/Akt signaling, we examined whether JNK and/or p38 MAPK are also involved in this signal pathway.
MTB-induced Akt phosphorylation was blocked by treatment with JNK- or p38 MAPK-specific inhibitors implying that p38 and JNK are upstream of Akt. In addition, treatment with the PI3-K-specific inhibitor inhibited MTB-stimulated activation of JNK or p38 MAPK implying that PI3-K is upstream of JNK and p38 MAPK. These results collectively suggest that JNK and p38MAPK are involved in the signal pathway responsible for MTB-induced up-regulation of Lkn-1. [BMB Reports 2012;45(10): 583-588]
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참고문헌 (23)
참고문헌 신청
A, S. K. / 2012 / ESAT-6 induced COX-2 expression involves coordinated
Algood, H. M. / 2003 / Chemokines and tuberculosis / Cytokine Growth Factor Rev. 14 : 467 ~ 477
Cooper, A. M. / 2008 / The role of cytokines in the initiation, expansion, and control of cellular immuniy to tuberculosis / Immunol. Rev. 226 : 191 ~ 204
Davis, J. M. / 2009 / The role of the granuloma in expansion and dissemination of early tuberculous infection / Cell 136 : 37 ~ 49
Fenton, M. J. / 1998 / Macrophages and tuberculosis / Curr. Opin. Hematol. 5 : 72 ~ 78
Algood, H. M. / 2003 / Chemokines and tuberculosis / Cytokine Growth Factor Rev. 14 : 467 ~ 477
Cooper, A. M. / 2008 / The role of cytokines in the initiation, expansion, and control of cellular immuniy to tuberculosis / Immunol. Rev. 226 : 191 ~ 204
Davis, J. M. / 2009 / The role of the granuloma in expansion and dissemination of early tuberculous infection / Cell 136 : 37 ~ 49
Fenton, M. J. / 1998 / Macrophages and tuberculosis / Curr. Opin. Hematol. 5 : 72 ~ 78
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