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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 466 - 471 (6page)
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The results of this study show that c-Jun N-terminal kinase (JNK) activation was associated with the enhancement of docetaxel-induced cytotoxicity by simvastatin in DU145 human prostate cancer cells. To better understand the basic molecular mechanisms, we investigated simvastatin-regulated targets during simvastatin-induced cell death in DU145 cells using two-dimensional (2D) proteomic analysis. Thus, vimentin, Ras-related protein Rab-1B (RAB1B), cytoplasmic hydroxymethylglutaryl-CoA synthase (cHMGCS), thioredoxin domain-containing protein 5 (TXNDC5), heterogeneous nuclear ribonucleoprotein K (hnRNP K), N-myc downstream-regulated gene 1 (NDRG1), and isopentenyl-diphosphate Delta-isomerase 1 (IDI1) protein spots were identified as simvastatin-regulated targets involved in DU145 cell death signaling pathways.
Moreover, the JNK inhibitor SP600125 significantly inhibited the upregulation of NDRG1 and IDI protein levels by combination treatment of docetaxel and simvastatin. These results suggest that NDRG1 and IDI could at least play an important role in DU145 cell death signaling as simvastatinregulated targets associated with JNK activation.
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참고문헌 (23)
참고문헌 신청
Altwairgi AK / 2015 / Statins are potential anticancerous agents (Review) / Oncol Rep 33 : 1019 ~ 1039
Bogoyevitch MA / 2008 / Inhibitors of c-Jun N-terminal kinases: JuNK no more? / Biochim Biophys Acta 1784 : 76 ~ 93
Campos-Martorell M / 2014 / Brain proteomics identifies potential simvastatin targets in acute phase of stroke in a rat embolic model / J Neurochem 130 : 301 ~ 312
Chen X / 2016 / Mechanistic study of inhibitory effects of atorvastatin and docetaxel in combination on prostate cancer / Cancer Genomics Proteomics 13 : 151 ~ 160
Chen YJ / 2014 / Simvastatin induces NF?B/p65 down-regulation and JNK1/c-Jun/ATF-2 activation, leading to matrix metalloproteinase-9 (MMP-9) but not MMP-2 down-regulation in
Bogoyevitch MA / 2008 / Inhibitors of c-Jun N-terminal kinases: JuNK no more? / Biochim Biophys Acta 1784 : 76 ~ 93
Campos-Martorell M / 2014 / Brain proteomics identifies potential simvastatin targets in acute phase of stroke in a rat embolic model / J Neurochem 130 : 301 ~ 312
Chen X / 2016 / Mechanistic study of inhibitory effects of atorvastatin and docetaxel in combination on prostate cancer / Cancer Genomics Proteomics 13 : 151 ~ 160
Chen YJ / 2014 / Simvastatin induces NF?B/p65 down-regulation and JNK1/c-Jun/ATF-2 activation, leading to matrix metalloproteinase-9 (MMP-9) but not MMP-2 down-regulation in
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