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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 691 - 695 (5page)
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We report that phytosphingosine, a sphingolipid found in many organisms and implicated in cellular signaling, promotes megakaryocytic differentiation of myeloid leukemia cells.
Specifically, phytosphingosine induced several hallmark changes associated with megakaryopoiesis from K562 and HEL cells including cell cycle arrest, cell size increase and polyploidization. We also confirmed that cell type specific markers of megakaryocytes, CD41a and CD42b are induced by phytosphingosine. Phospholipids with highly similar structures were unable to induce similar changes, indicating that the activity of phytosphingosine is highly specific. Although phytosphingosine is known to activate p38 mitogen-activated protein kinase (MAPK)-mediated apoptosis, the signaling mechanisms involved in megakaryopoiesis appear to be distinct. In sum, we present another model for dissecting molecular details of megakaryocytic differentiation which in large part remains obscure.
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참고문헌 (12)
참고문헌 신청
Caihong Zhou / 2013 / Overexpression of TTRAP inhibits cell growth and induces apoptosis in osteosarcoma cells / BMB Reports 46 (2) : 113 ~ 118
Columbyova L / 1995 / Thrombopoietin receptor expression in human cancer cell lines and primary tissues / Cancer Res 55 : 3509 ~ 3512
Deutsch VR / 2006 / Megakaryocyte development and platelet production / Br J Haematol 134 : 453 ~ 466
Jalagadugula G / 2006 / Early growth response transcription factor EGR-1 regulates Galphaq gene in megakaryocytic cells / J Thromb Haemost 4 : 2678 ~ 2686
Kaushansky K / 2002 / The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production / Oncogene 21 : 3359 ~ 3367
Columbyova L / 1995 / Thrombopoietin receptor expression in human cancer cell lines and primary tissues / Cancer Res 55 : 3509 ~ 3512
Deutsch VR / 2006 / Megakaryocyte development and platelet production / Br J Haematol 134 : 453 ~ 466
Jalagadugula G / 2006 / Early growth response transcription factor EGR-1 regulates Galphaq gene in megakaryocytic cells / J Thromb Haemost 4 : 2678 ~ 2686
Kaushansky K / 2002 / The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production / Oncogene 21 : 3359 ~ 3367
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