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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 437 - 442 (6page)
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We aimed to study the role of protein L-isoaspartyl methyltransferase (PIMT) in neuronal differentiation using basic fibroblast growth factor (bFGF)-induced neuronal differentiation, characterized by cell-body shrinkage, long neurite outgrowth, and expression of neuronal differentiation markers light and medium neurofilaments (NF). The bFGF-mediated neuronal differentiation of PC12 cells was induced through activation of mitogen-activated protein kinase (MAPK) signaling molecules [MAPK kinase 1/2 (MEK1/2), extracellular signal-regulated kinase 1/2 (ERK1/2), and p90RSK], and phosphatidylinositide 3-kinase (PI3K)/Akt signaling molecules PI3Kp110, PI3Kp110, Akt, and mTOR. Inhibitors (adenosine dialdehyde and S-adenosylhomocysteine) of protein methylation suppressed bFGF-mediated neuronal differentiation of PC12 cells. PIMTeficiency caused by PIMT-specific siRNA inhibited neuronal differentiation of PC12 cells by suppressing phosphorylation of MEK1/2 and ERK1/2 in the MAPK signaling pathway and Akt and mTOR in the PI3K/Akt signaling pathway. Therefore, these results suggested that PIMT was critical for bFGF-mediated neuronal differentiation of PC12 cells and regulated the MAPK and Akt signaling pathways.
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참고문헌 (41)
참고문헌 신청
Ma Q / 2006 / Transcriptional regulation of neuronal phenotype in mammals / J Physiol 575:379~387
Feng Z / 1999 / NF-kappaB/Rel proteins are required for neuronal differentiation of SH-SY5Y neuroblastoma cells / J Biol Chem 274:30341~30344
Leppa S / 2001 / Complex functions of AP-1 transcription factors in differentiation and survival of PC12 cells / Mol Cell Biol 21:4369~4378
Woodbury D / 2000 / Adult rat and human bone marrow stromal cells differentiate into neurons / J Neurosci Res 61:364~370
Doniach T / 1995 / Basic FGF as an inducer of anteroposterior neural pattern / Cell 83:1067~1070
Feng Z / 1999 / NF-kappaB/Rel proteins are required for neuronal differentiation of SH-SY5Y neuroblastoma cells / J Biol Chem 274:30341~30344
Leppa S / 2001 / Complex functions of AP-1 transcription factors in differentiation and survival of PC12 cells / Mol Cell Biol 21:4369~4378
Woodbury D / 2000 / Adult rat and human bone marrow stromal cells differentiate into neurons / J Neurosci Res 61:364~370
Doniach T / 1995 / Basic FGF as an inducer of anteroposterior neural pattern / Cell 83:1067~1070
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