지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 371 - 372 (2page)
이용수
초록· 키워드
오류제보하기
Cardiovascular disease such as atherosclerosis is caused by imbalanced lipid metabolism and represents a leading cause of death worldwide. Epidemiological studies show that patients with systemic autoimmune diseases exhibit a higher incidence of atherosclerosis. Conversely, hyperlipidemia has been known to accelerate the incidence of autoimmune diseases in humans and in animal models. However, there is a considerable gap in our understanding of how atherosclerosis impacts the development of the autoimmunity in humans, and vice versa. The atherosclerosis-related autoimmune diseases include psoriasis, rheumatoid arthritis, systemic lupus erythematosus (SLE) and diabetes mellitus. By using animal models of atherosclerosis and SLE, we have recently demonstrated that hyperlipidemia significantly accelerates the development of autoantibodies, by inducing autoimmune follicular helper T (TFH) cells. Mechanistic studies have identified that hyperlipidemia induces IL-27 production in a TLR4-dependent manner, likely via downregulating LXR expression in dendritic cells. In this case, mice lacking IL-27 do not develop enhanced antibody responses. Thus it is noted that these findings propose a mechanistic insight responsible for the tight association between cardiovascular diseases and SLE in humans.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Development of the Treatment for Autoimmune Diseases/Inflammatory Diseases by Controlling Toll-like Receptor Signal
한국생물공학회 학술대회
2020 .06
-
High density lipoprotein mimicking nanoparticles for atherosclerosis
Nano Convergence
2020 .01
-
결함허용 양자 컴퓨팅을 위한 양자 오류 복호기 연구 동향
[ETRI] 전자통신동향분석
2023 .10
-
Biomimetic Prohealing Nanomatrix for Stent and Atherosclerosis Model
한국고분자학회 학술대회 연구논문 초록집
2021 .04
-
Nanomedicine for the Treatment of Atherosclerosis
한국생물공학회 학술대회
2021 .10
-
Disturbed Flow-targeting Nanovesicles as a New Therapeutic for Atherosclerosis
한국생물공학회 학술대회
2022 .04
-
Combined application of rapamycin and atorvastatin improves lipid metabolism in apolipoprotein E-deficient mice with chronic kidney disease
BMB Reports
2021 .01
-
동맥경화의 미세환경에서 대식세포의 사멸에 의한 혈관세포의 기능적 변화에 대한 가시화
한국가시화정보학회지
2017 .12
-
Endothelial dysfunction induces atherosclerosis: increased aggrecan expression promotes apoptosis in vascular smooth muscle cells
BMB Reports
2019 .01
-
Telomere stabilization by metformin mitigates the progression of atherosclerosis via the AMPK-dependent p-PGC-1α pathway
Experimental and Molecular Medicine
2024 .09
-
The enhanced expression of IL-17-secreting T cells during the early progression of atherosclerosis in ApoE-deficient mice fed on a western-type diet
Experimental and Molecular Medicine
2015 .01
-
Locus of (IL-9) control: IL9 epigenetic regulation in cellular function and human disease
Experimental and Molecular Medicine
2024 .06
-
심우주 지상 안테나 시스템 SLE 접속 기능 검증
한국항공우주학회 학술발표회 초록집
2020 .11
-
Estrogen receptor α in T cells suppresses follicular helper T cell responses and prevents autoimmunity
Experimental and Molecular Medicine
2019 .01
-
Therapeutic effect of dichloroacetate against atherosclerosis via hepatic FGF21 induction mediated by acute AMPK activation
Experimental and Molecular Medicine
2019 .01
-
A cell-penetrating peptide blocks Toll-like receptor-mediated downstream signaling and ameliorates autoimmune and inflammatory diseases in mice
Experimental and Molecular Medicine
2019 .01
-
A critical role for Th17 cell-derived TGF-β1 in regulating the stability and pathogenicity of autoimmune Th17 cells
Experimental and Molecular Medicine
2021 .05
-
Pycnogenol attenuates atherosclerosis by regulating lipid metabolism through the TLR4–NF-κB pathway
Experimental and Molecular Medicine
2015 .01
-
Generation and characterization of integration-free induced pluripotent stem cells from patients with autoimmune disease
Experimental and Molecular Medicine
2016 .01
-
A neutrophil elastase-generated mature form of IL-33 is a potent regulator of endothelial cell activation and proliferative retinopathy
Experimental and Molecular Medicine
2024 .08
이 논문의 저자 정보
최근 본 자료
댓글(0)
0