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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 145 - 150 (6page)
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초록· 키워드
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Endothelial dysfunction-induced lipid retention is an early feature of atherosclerotic lesion formation. Apoptosis of vascular smooth muscle cells (VSMCs) is one of the major modulating factors of atherogenesis, which accelerates atherosclerosis progression by causing plaque destabilization and rupture. However, the mechanism underlying VSMC apoptosis mediated by endothelial dysfunction in relation to atherosclerosis remains elusive. In this study, we reveal differential expression of several genes related to lipid retention and apoptosis, in conjunction with atherosclerosis, by utilizing a genetic mouse model of endothelial nitric oxide synthase (eNOS) deficiency manifesting endothelial dysfunction. Moreover, eNOS deficiency led to the enhanced susceptibility against pro-apoptotic insult in VSMCs. In particular, the expression of aggrecan, a major proteoglycan, was elevated in aortic tissue of eNOS deficient mice compared to wild type mice, and administration of aggrecan induced apoptosis in VSMCs. This suggests that eNOS deficiency may elevate aggrecan expression, which promotes apoptosis in VSMC, thereby contributing to atherosclerosis progression. These results may facilitate the development of novel approaches for improving the diagnosis or treatment of atherosclerosis.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Furchgott RF / 1980 / The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine / Nature 288:373~376
Davignon J / 2004 / Role of endothelial dysfunction in atherosclerosis / Circulation 109:iii27~iii32
Mooradian DL / 1995 / Nitric oxide(NO)donor molecules : effect of NO release rate on vascular smooth muscle cell proliferation in vitro / J Cardiovasc Pharmacol 25:674~678
Ponnuswamy P / 2012 / eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice / PLoS One 7:e30193
Flammer AJ / 2012 / The assessment of endothelial function : from research into clinical practice / Circulation 126:753~767
Davignon J / 2004 / Role of endothelial dysfunction in atherosclerosis / Circulation 109:iii27~iii32
Mooradian DL / 1995 / Nitric oxide(NO)donor molecules : effect of NO release rate on vascular smooth muscle cell proliferation in vitro / J Cardiovasc Pharmacol 25:674~678
Ponnuswamy P / 2012 / eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice / PLoS One 7:e30193
Flammer AJ / 2012 / The assessment of endothelial function : from research into clinical practice / Circulation 126:753~767
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