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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
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- 1 - 9 (9page)
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Atherosclerosis is a leading cause of death worldwide and is characterized by lipid-laden foam cell formation. Recently,pycnogenol (PYC) has drawn much attention because of its prominent effect on cardiovascular disease (CVD). However, its protective effect against atherosclerosis and the underlying mechanism remains undefined. Here PYC treatment reduced areas of plaque and lipid deposition in atherosclerotic mice, concomitant with decreases in total cholesterol and triglyceride levels and increases in HDL cholesterol levels, indicating a potential antiatherosclerotic effect of PYC through the regulation of lipid levels.
Additionally, PYC preconditioning markedly decreased foam cell formation and lipid accumulation in lipopolysaccharide (LPS)-stimulated human THP-1 monocytes. A mechanistic analysis indicated that PYC decreased the lipid-related protein expression of adipose differentiation-related protein (ADRP) and adipocyte lipid-binding protein (ALBP/aP2) in a dose-dependent manner. Further analysis confirmed that PYC attenuated LPS-induced lipid droplet formation via ADRP and ALBP expression through the Toll-like receptor 4 (TLR4) and nuclear factor-κB (NF-κB) pathway, because pretreatment with anti-TLR4 antibody or a specific inhibitor of NF-κB (PDTC) strikingly mitigated the LPS-induced increase in ADRP and ALBP. Together, our results provide insight into the ability of PYC to attenuate bacterial infection-triggered pathological processes associated with atherosclerosis. Thus PYC may be a potential lead compound for the future development of antiatherosclerotic CVD therapy.
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참고문헌 (22)
참고문헌 신청
Cai Y / 2013 / Vinpocetine attenuates lipid accumulation and atherosclerosis formation / Biochem Biophys Res Commun 434 : 439 ~ 443
Chapman KD / 2012 / Biogenesis and functions of lipid droplets in plants : Thematic Review Series : Lipid Droplet Synthesis and Metabolism : from Yeast to Man / J Lipid Res
Enseleit F / 2012 / Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over
Favero G / 2014 / Endothelium and its alterations in cardiovascular diseases : life style intervention / Biomed Res Int 2014 : 801896 ~
Feng X. / 2011 / Natural IgM specific for oxLDL protects murine macrophages from foam cells formation but lipopolysaccharide (LPS) disrupts the course by up-regulating the e
Chapman KD / 2012 / Biogenesis and functions of lipid droplets in plants : Thematic Review Series : Lipid Droplet Synthesis and Metabolism : from Yeast to Man / J Lipid Res
Enseleit F / 2012 / Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over
Favero G / 2014 / Endothelium and its alterations in cardiovascular diseases : life style intervention / Biomed Res Int 2014 : 801896 ~
Feng X. / 2011 / Natural IgM specific for oxLDL protects murine macrophages from foam cells formation but lipopolysaccharide (LPS) disrupts the course by up-regulating the e
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