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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 601 - 609 (9page)
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초록· 키워드
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Mammalian target of rapamycin complex 1 (mTORC1) plays a major role in cell growth, proliferation, polarity, differentiation, development, and controls transitioning between anabolic and catabolic states of the cell. It collects almost all extracellular and intracellular signals from growth factors, nutrients, and maintains cellular homeostasis, and is involved in several pathological conditions including, neurodegeneration, Type 2 diabetes (T2D), obesity, and cancer. In this review, we summarize current knowledge of upstream signaling of mTORC1 to explain etiology of T2D and hypertriglyceridemia, in which state, the role of telomere attrition is explained. We discuss if chronic inhibition of mTORC1 can reverse adverse effects resulting from hyperactivation. In conclusion, we suggest the regulatory roles of telomerase (TERT) and hexokinase II (HKII) on mTORC1 as possible remedies to treat hyperactivation. The former inhibits mTORC1 under nutrientrich while the latter under starved condition. We provide an idea of TOS (TOR signaling) motifs that can be used for regulation of mTORC1.
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참고문헌 (28)
참고문헌 신청
Ali M / 2016 / Telomerase reverse transcriptase induces basal and amino acid starvation-induced autophagy through mTORC1 / Biochem Biophys Res Commun 478 : 1198 ~ 1204
Avila-Flores A / 2005 / Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid / J Biol Chem 280 : 10091 ~ 10099
Chantranupong L / 2014 / The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1 / Cell Rep 9 : 1 ~ 8
Cheng H / 2015 / Telomerase deficiency delays renal recovery in mice after ischemia-reperfusion injury by impairing autophagy / Kidney Int 88 : 85 ~ 94
Cybulski N / 2009 / TOR complex 2: a signaling pathway of its own / Trends in Biochemical Sciences 34 : 620 ~ 627
Avila-Flores A / 2005 / Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid / J Biol Chem 280 : 10091 ~ 10099
Chantranupong L / 2014 / The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1 / Cell Rep 9 : 1 ~ 8
Cheng H / 2015 / Telomerase deficiency delays renal recovery in mice after ischemia-reperfusion injury by impairing autophagy / Kidney Int 88 : 85 ~ 94
Cybulski N / 2009 / TOR complex 2: a signaling pathway of its own / Trends in Biochemical Sciences 34 : 620 ~ 627
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