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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 458 - 465 (8page)
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Metastasis is the main culprit of the great majority of cancerrelated deaths. However, the complicated process of the invasion- metastasis cascade remains the least understood aspect of cancer biology. Telomerase plays a pivotal role in bypassing cellular senescence and sustaining the cancer progression by maintaining telomere homeostasis and genomic integrity. Telomerase reverse transcriptase (TERT) exerts a series of fundamental functions that are independent of its enzymatic cellular activity, including proliferation, inflammation, epithelia-mesenchymal transition (EMT), angiogenesis, DNA repair, and gene expression. Accumulating evidence indicates that TERT may facilitate most steps of the invasion-metastasis cascade. In this review, we summarize important advances that have revealed some of the mechanisms by which TERT facilitates tumor metastasis, providing an update on the non-canonical functions of telomerase beyond telomere maintaining.
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참고문헌 (94)
참고문헌 신청
Finkel T / 2007 / The common biology of cancer and ageing / Nature 448:767~774
Palm W / 2008 / How shelterin protects mammalian telomeres / Annu Rev Genet 42:301~334
Arndt GM / 2016 / New prospects for targeting telomerase beyond the telomere / Nat Rev Cancer 16:508~524
Yi X / 1999 / Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels / Mol Cell Biol 19:3989~3997
Cong Y / 2008 / Actions of human telomerase beyond telomeres / Cell Res 18:725~732
Palm W / 2008 / How shelterin protects mammalian telomeres / Annu Rev Genet 42:301~334
Arndt GM / 2016 / New prospects for targeting telomerase beyond the telomere / Nat Rev Cancer 16:508~524
Yi X / 1999 / Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels / Mol Cell Biol 19:3989~3997
Cong Y / 2008 / Actions of human telomerase beyond telomeres / Cell Res 18:725~732
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