지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 14 (14page)
이용수
초록· 키워드
오류제보하기
The mammalian target of rapamycin (mTOR) signaling pathway efficiently regulates the energy state of cells and maintains tissue homeostasis. Dysregulation of the mTOR pathway has been implicated in several human diseases. Rapamycin is a specific inhibitor of mTOR and pharmacological inhibition of mTOR with rapamycin promote cardiac cell generation from the differentiation of mouse and human embryonic stem cells. These studies strongly implicate a role of sustained mTOR activity in the differentiating functions of embryonic stem cells; however, they do not directly address the required effect for sustained mTOR activity in human cardiac progenitor cells. In the present study, we evaluated the effect of mTOR inhibition by rapamycin on the cellular function of human cardiac progenitor cells and discovered that treatment with rapamycin markedly attenuated replicative cell senescence in human cardiac progenitor cells (hCPCs) and promoted their cellular functions. Furthermore, rapamycin not only inhibited mTOR signaling but also influenced signaling pathways, including STAT3 and PIM1, in hCPCs. Therefore, these data reveal a crucial function for rapamycin in senescent hCPCs and provide clinical strategies based on chronic mTOR activity.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Rapamycin-resistant and torin-sensitive mTOR signaling promotes the survival and proliferation of leukemic cells
BMB Reports
2016 .01
-
The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance
Experimental and Molecular Medicine
2016 .01
-
Long and Short-Term Effect of mTOR Regulation on Cerebral Organoid Growth and Differentiations
조직공학과 재생의학
2024 .01
-
mTOR Plays an Important Role in the Stemness of Human Fetal Cartilage Progenitor Cells (hFCPCs)
조직공학과 재생의학
2024 .02
-
심근유래의 줄기세포 프라이밍 및 조직공학 기술에 의한 심혈관 재생 전략
KSBB Journal
2018 .09
-
Cell Cycle Arrest Effects of Extract from Artemisia annuain through Akt/mTOR Signaling Pathway in HCT116 Colon Cancer Cells
한국생물공학회 학술대회
2015 .04
-
Extracts fromCinnamomumcamphorainduce G1 Cell Cycle Arrest in HCT116 Colon Cancer Cells via Regulating of Akt/mTOR/p53 signaling Pathway
한국생물공학회 학술대회
2018 .04
-
HCT116 대장암세포에서 Akt-mTOR 신호경로를 통한 개똥쑥 추출물(AAE)의 세포주기 억제 효과
KSBB Journal
2015 .10
-
Brain somatic mutations in MTOR leading to focal cortical dysplasia
BMB Reports
2016 .01
-
Apoptotic Effects of Extracts from Allium Hookeri through Regulating Akt/mTOR/p53 Signaling Pathways in AGS Human Gastric Carcinoma Cells
한국생물공학회 학술대회
2018 .04
-
Development of TAT-fused mTOR Inhibitor Binding Proteins for the Treatment of Breast Cancer
한국생물공학회 학술대회
2022 .04
-
Glucosamine increases macrophage lipid accumulation by regulating the mammalian target of rapamycin signaling pathway
BMB Reports
2024 .02
-
Comparative global immune-related gene profiling of somatic cells, human pluripotent stem cells and their derivatives: implication for human lymphocyte proliferation
Experimental and Molecular Medicine
2017 .01
-
Regulation of autophagy by perilysosomal calcium: a new player in β-cell lipotoxicity
Experimental and Molecular Medicine
2024 .02
-
mTOR signalling pathway - A root cause for idiopathic autism?
BMB Reports
2019 .01
-
Engineered M13 Peptide Carrier Promotes Angiogenic Potential of Patient-Derived Human Cardiac Progenitor Cells and In Vivo Engraftment
조직공학과 재생의학
2020 .01
-
Biogenic Selenium Nanoparticle Induces Apoptosis and Autophagy in Human Gastric Cancer Cells by Suppressing the PI3K/AKT/mTOR Signaling Pathway
한국생물공학회 학술대회
2022 .04
-
Stem cell maintenance by manipulating signaling pathways: past, current and future
BMB Reports
2015 .01
-
Extracellular Vesicles from Adipose-Derived Stem Cells Promote Diabetic Wound Healing via the PI3K-AKT-mTOR-HIF-1α Signaling Pathway
조직공학과 재생의학
2021 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0