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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 615 - 620 (6page)
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Fibronectin (FN) plays important roles in the EMT in a variety of cancer cell types. However, the mechanism by which FN expression is regulated in tamoxifen-resistant (TamR) breast cancer cells has not yet been fully elucidated. Aberrant FN expression was associated with poor prognosis in patients with luminal type A breast cancer. In addition, FN was upregulated in TamR cells. To investigate the mechanism by which FN expression is regulated, we assessed the levels of phosphorylated Akt, JNK, and STAT3 and found that they were all increased in TamR cells. Induction of FN expression was dampened by LY294002 or AKT IV in TamR cells. Furthermore, FN expression was increased by constitutively active (CA)-Akt overexpression in tamoxifen-sensitive MCF7 (TamS) cells and colony formation of TamR cells was blocked by AKT IV treatment. Taken together, these results demonstrate that FN expression is upregulated through the PI-3K/Akt pathway in tamoxifen-resistant breast cancer cells.
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참고문헌 (23)
참고문헌 신청
Ali S / 2002 / Endocrine-responsive breast cancer and strategies for combating resistance / Nat Rev Cancer 2 : 101 ~ 112
Anzick SL / 1997 / AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer / Science 277 : 965 ~ 968
Arpino G / 2004 / HER-2 amplification, HER-1 expression, and tamoxifen response in estrogen receptor-positive metastatic breast cancer: a southwest oncology group study / Cl
Bae YK / 2013 / Fibronectin expression in carcinoma cells correlates with tumor aggressiveness and poor clinical outcome in patients with invasive breast cancer / Hum Pathol
Beiki O / 2012 / Breast cancer incidence and case fatality among 4.7 million women in relation to social and ethnic background: a population-based cohort study / Breast Cance
Anzick SL / 1997 / AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer / Science 277 : 965 ~ 968
Arpino G / 2004 / HER-2 amplification, HER-1 expression, and tamoxifen response in estrogen receptor-positive metastatic breast cancer: a southwest oncology group study / Cl
Bae YK / 2013 / Fibronectin expression in carcinoma cells correlates with tumor aggressiveness and poor clinical outcome in patients with invasive breast cancer / Hum Pathol
Beiki O / 2012 / Breast cancer incidence and case fatality among 4.7 million women in relation to social and ethnic background: a population-based cohort study / Breast Cance
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