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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 284 - 289 (6page)
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Tamoxifen, a nonsteroidal estrogen receptor (ER) antagonist, is used routinely as a chemotherapeutic agent for ER-positive breast cancer. However, it is also causes side effects, including retinotoxicity. The retinal pigment epithelium (RPE) has been recognized as the primary target of tamoxifen-induced retinotoxicity. The RPE plays an essential physiological role in the normal functioning of the retina. Nonetheless, potential therapeutic agents to prevent tamoxifen-induced retinotoxicity in breast cancer patients have not been investigated. Here, we evaluated the action mechanisms of sulfasalazine against tamoxifen- induced RPE cell death. Tamoxifen induced reactive oxygen species (ROS)-mediated autophagic cell death and caspase-1- mediated pyroptosis in RPE cells. However, sulfasalazine reduced tamoxifen-induced total ROS and ROS-mediated autophagic RPE cell death. Also, mRNA levels of tamoxifen-induced pyroptosis-related genes, IL-1, NLRP3, and procaspase-1, also decreased in the presence of sulfasalazine in RPE cells. Additionally, the mRNA levels of tamoxifen-induced AMD-related genes, such as complement factor I (CFI), complement factor H (CFH), apolipoprotein E (APOE), apolipoprotein J (APOJ), toll-like receptor 2 (TLR2) and toll-like receptor 4 (TLR4), were downregulated in RPE cells. Together, these data provide novel insight into the therapeutic effects of sulfasalazine against tamoxifen-induced RPE cell death.
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참고문헌 (13)
참고문헌 신청
Xiong R / 2017 / Novel SERDs Developed against treatment-resistant breast cancer / J Med Chem 60:1325~1342
Yang G / 2013 / Toxicity and adverse effects of tamoxifen and other anti-estrogen drugs / Pharmacol Ther 139:392~404
Wang L / 2015 / Tamoxifen retinopathy : a case report / Springerplus 4:501
Kim LA / 2014 / Tamoxifen toxicity in cultured RPE cells is mediated by concurrent regulated cell death mechanisms / Invest Ophthalmol Vis Sci 55:4747~4758
Koulisis N / 2016 / The tipping point : Tamoxifen toxicity, central serous chorioretinopathy, and the role of estrogen and its receptors / Am J Ophthalmol Case Rep 3:8~13
Yang G / 2013 / Toxicity and adverse effects of tamoxifen and other anti-estrogen drugs / Pharmacol Ther 139:392~404
Wang L / 2015 / Tamoxifen retinopathy : a case report / Springerplus 4:501
Kim LA / 2014 / Tamoxifen toxicity in cultured RPE cells is mediated by concurrent regulated cell death mechanisms / Invest Ophthalmol Vis Sci 55:4747~4758
Koulisis N / 2016 / The tipping point : Tamoxifen toxicity, central serous chorioretinopathy, and the role of estrogen and its receptors / Am J Ophthalmol Case Rep 3:8~13
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