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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.8
- 수록면
- 233 - 244 (12page)
- DOI
- http://dx.doi.org/10.14397/jals.2015.49.4.233
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초록· 키워드
오류제보하기
To investigate the in vivo cognitive effects of syringic acid(SA), Y-maze and passiveavoidance tests were performed in amyloid-β(Aβ)-induced cytotoxicity. Learning and memoryimpairment by Aβ neurotoxicity was partially recovered in Institute of Cancer Research(ICR)mice orally administered SA(10mg/kg of body weight). The SA treated group showed aninhibitory effect on acetylcholinesterase(AChE) that was extracted from mice brain tissue after invivo tests. Aβ-induced oxidative stress was also examined by malondialdehyde(MDA) and2',7,-dichlorofluorescein diacetate(DCF-DA) assays, and lipid peroxidation of brain homogenatesand cellular oxidative stress were reduced by SA. In cell viability assays using3-[4,5-dimethythiazol-2-yl]-2,5-diphenyl tetrazolium bromide(MTT), lactate dehydrogenase(LDH)leakage, and caspase 3/7 activity, the SA treated group showed relatively effective protectionagainst Aβ-induced neurotoxicity compared to the others. Consequently, these results suggest thatSA in black soybean seed coat extract might improve cognitive function because of its neuronalcell protective effects against oxidative stress and the inhibitory effect of AChE as a cholinergicenzyme.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Abe K / 2000 / Measurement of cellular3-(4, 5-dimethylthiazol-2-yl) - 2 , 5 - diphenyltetrazolium bromide(MTT) reduction activity and lactate dehydrogenase release using MTT / Neurosci. Res 38:325~329
Preet Anand / 2013 / A review on cholinesterase inhibitors for Alzheimer’s disease / Archives of Pharmacal Research 36(4):375~399
Bryan-Sisneros AA / 1993 / Toxic effect of the beta-amyloid precursor protein scolopamin induced hypermolility in rats / Pharm. Pharmacol 45:841~843
Butterfield DA / 2001 / Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide / Trends. Mol. Med 7:548~554
Chang NS / 2001 / Antioxidative effects of green tea power diet against ethanol-induced oxidative damage in rat brain regions / J. Nutr. Health 34:525~531
Preet Anand / 2013 / A review on cholinesterase inhibitors for Alzheimer’s disease / Archives of Pharmacal Research 36(4):375~399
Bryan-Sisneros AA / 1993 / Toxic effect of the beta-amyloid precursor protein scolopamin induced hypermolility in rats / Pharm. Pharmacol 45:841~843
Butterfield DA / 2001 / Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide / Trends. Mol. Med 7:548~554
Chang NS / 2001 / Antioxidative effects of green tea power diet against ethanol-induced oxidative damage in rat brain regions / J. Nutr. Health 34:525~531
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