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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 554 - 560 (7page)
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Smad4 is involved in cancer progression and metastasis. Using a pair of human syngeneic epithelial ovarian cancer cells with low (HO-8910) and high (HO-8910PM) metastatic abilities, we aimed to reveal the role of Smad4 in ovarian cancer metastasis in vitro. Smad4 was down-regulated in HO-8910PM cell line relative to HO-8910 by implicating Smad4 was probably a potential tumor suppressor gene for ovarian cancer. Re-expression of Smad4 decreased the migration ability and inhibited the invasion capacity of HO-8910PM, while promoted the cell adhesion capacity for HO-8910PM. The stable expression of Smad4 increased the expression of E-cadherin, reduced the expression of plasminogen activator inhibitor-1(PAI-1) and slightly down-regulated the expression of VEGF.
Smad4 suppresses human ovarian cancer cell metastasis potential through its effect on the expressions of PAI-1, E-cadherin and VEGF. Results from current work implicate Smad4might suppress the invasion and metastasis of human ovarian tumor cells through a TGF-β/Smad-mediated pathway.
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참고문헌 (25)
참고문헌 신청
Benest, A. V. / 2009 / Cancer: blood vessels kept quiet / Nature 458 : 41 ~ 42
Chen, H. / 2009 / TGF-beta induced fibroblast activation protein expression, fibroblast activation protein expression increases the proliferation, adhesion, and migration of
Crawford, Y. / 2009 / VEGF inhibition: insights from preclinical and clinical studies / Cell Tissue. Res. 335 : 261 ~ 26
Dai, L. / 2009 / TWEAK promotes ovarian cancer cell metastasis via NF-kappaB pathway activation and VEGF expression / Cancer Lett. 283 : 159 ~ 167
Hahn, S. A. / 1996 / DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1 / Science 271 : 350 ~ 353
Chen, H. / 2009 / TGF-beta induced fibroblast activation protein expression, fibroblast activation protein expression increases the proliferation, adhesion, and migration of
Crawford, Y. / 2009 / VEGF inhibition: insights from preclinical and clinical studies / Cell Tissue. Res. 335 : 261 ~ 26
Dai, L. / 2009 / TWEAK promotes ovarian cancer cell metastasis via NF-kappaB pathway activation and VEGF expression / Cancer Lett. 283 : 159 ~ 167
Hahn, S. A. / 1996 / DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1 / Science 271 : 350 ~ 353
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