지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 139 - 144 (6page)
이용수
초록· 키워드
오류제보하기
Breast cancer (BRC) is the most invasive cancer in women. Although the survival rate of BRC is gradually increasing due to improved screening systems, development of novel therapeutic targets for inhibition of BRC proliferation, metastasis and recurrence have been constantly needed. Thus, in this study, we identified overexpression of SETDB1 (SET Domain Bifurcated 1), a histone methyltransferase, in RNA-seq data of BRC derived from TCGA portal. In Gene Ontology (GO) analysis, cell migration-related GO terms were enriched, and we confirmed down-regulation of cell migration/invasion and alteration of EMT /MET markers after knockdown of SETDB1. Moreover, gene network analysis showed that SMAD7 expression is regulated by SETDB1 levels, indicating that up-regulation of SMAD7 by SETDB1 knockdown inhibited BRC metastasis. Therefore, development of SETDB1 inhibitors and functional studies may help develop more effective clinical guidelines for BRC treatment.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Dent R / 2007 / Triple-negative breast cancer : clinical features and patterns of recurrence / Clin Cancer Res 13:4429~4434
Lee A / 2017 / Triple negative breast cancer : Emerging therapeutic modalities and novel combination therapies / Cancer Treat Rev 62:110~122
박재인 / 2018 / BLT2, a leukotriene B4 receptor 2, as a novel prognostic biomarker of triple-negative breast cancer / BMB Reports 51(8):373~377
Kim K / 2018 / EHMT2is a metastasis regulator in breast cancer / Biochem Biophys Res Commun 496:758~762
Hongming Song / 2018 / MicroRNA-301b promotes cell proliferation and apoptosis resistance in triple-negative breast cancer by targeting CYLD / BMB Reports 51(11):602~607
Lee A / 2017 / Triple negative breast cancer : Emerging therapeutic modalities and novel combination therapies / Cancer Treat Rev 62:110~122
박재인 / 2018 / BLT2, a leukotriene B4 receptor 2, as a novel prognostic biomarker of triple-negative breast cancer / BMB Reports 51(8):373~377
Kim K / 2018 / EHMT2is a metastasis regulator in breast cancer / Biochem Biophys Res Commun 496:758~762
Hongming Song / 2018 / MicroRNA-301b promotes cell proliferation and apoptosis resistance in triple-negative breast cancer by targeting CYLD / BMB Reports 51(11):602~607
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
SETDB1 mediated FosB expression increases the cell proliferation rate during anticancer drug therapy
BMB Reports
2016 .01
-
Advanced Bioethanol Production from Hardwoods by BRC Sequential Fermentation
한국에너지학회 학술발표회
2019 .05
-
Converting Mandarin Peel Waste into Value Added bioethanol through BRC Enzymatic Bioprocess
한국에너지학회 학술발표회
2019 .05
-
Paenibacillus jamilae BRC15-1의 Cellulase 생산 최적화
KSBB Journal
2015 .12
-
화학적·광학적·분광학적 방법을 이용한 광주 도심지역 여름철 초미세먼지의 특성
PARTICLE AND AEROSOL RESEARCH
2021 .12
-
Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis
Experimental and Molecular Medicine
2023 .05
-
Comparable Influencing Factors to evaluate the Phosphate Removal on the Batch and the fix-bed Column by Converter Slag
상하수도학회지
2015 .01
-
유방암 전이 관련 핵심 유전자를 이용한 기계학습 예측 모델
한국정보과학회 학술발표논문집
2021 .06
-
Absorption properties and size distribution of aerosol particles during the fall season at an urban site of Gwangju, Korea
Environmental Engineering Research
2019 .03
-
청광차단 안경렌즈가 스마트패드를 이용한 근거리 작업 시 가독성 및 피로도에 미치는 영향
한국안광학회지
2017 .03
-
Smad4 controls bone homeostasis through regulation of osteoblast/osteocyte viability
Experimental and Molecular Medicine
2016 .01
-
Exosomes Derived from Human Adipose Mesenchymal Stem Cells Inhibits Fibrosis and Treats Oral Submucous Fibrosis via the miR-181a-5p/Smad2 Axis
조직공학과 재생의학
2024 .01
-
Particulate matter promotes cancer metastasis through increased HBEGF expression in macrophages
Experimental and Molecular Medicine
2022 .11
-
TP53I11 suppresses epithelial-mesenchymal transition and metastasis of breast cancer cells
BMB Reports
2019 .01
-
MBRC 기법을 적용한 AST 모델 기반 호흡음 분류 성능 분석
대한전자공학회 학술대회
2024 .06
-
Tubeimoside-1 suppresses breast cancer metastasis through downregulation of CXCR4 chemokine receptor expression
BMB Reports
2016 .01
-
MicroRNAs: promising biomarkers for diagnosis and therapeutic targets in human colorectal cancer metastasis
BMB Reports
2015 .01
-
수선필요도와 비용부담도 평가를 통한 공동주택 수선공사 핵심항목 도출방안
KIEAE Journal
2016 .08
-
MicroRNA-152-5p inhibits proliferation and migration and promotes apoptosis by regulating expression of Smad3 in human keloid fibroblasts
BMB Reports
2019 .01
-
유방암세포 성장과 Bmi-1 발현에 대한 레스베라트롤의 억제 효과
KSBB Journal
2017 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0