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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 18 - 25 (8page)
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Recent evidence has indicated that nano-sized vesicles called “exosomes” mediate the interaction between cancer cells and their microenvironment and play a critical role in the development of cancers. Exosomes contain cargo consisting of proteins, lipids, mRNAs, and microRNAs that can be delivered to different types of cells in nascent as well as distant locations. Cancer cell-derived exosomes (CCEs) have been identified in body fluids such as urine, plasma, and saliva from patients with cancer. Although their content depends on tumor type and stage, CCEs merit consideration as prognostic and diagnostic markers, as vehicles for drug delivery, and as potential therapeutic targets because they could transport various oncogenic elements. In this review, we summarize recent advances regarding the role of CCEs in cancer invasion and metastasis, as well as its potential clinical applications.
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참고문헌 (72)
참고문헌 신청
Raposo G / 2013 / Extracellular vesicles:exosomes, microvesicles, and friends / J Cell Biol 200:373~383
EL Andaloussi S / 2013 / Extracellular vesicles: biology, emerging therapeutic opportunities / Nat Rev Drug Discov 12:347~357
Johnstone RM / 1987 / Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles(exosomes) / J Biol Chem 262:9412~9420
Vlassov AV / 2012 / Exosomes : Current knowledge of their composition, biological functions, , diagnostic, therapeutic potentials / Biochim Biophys Acta 1820:940~948
Kharaziha P / 2012 / Tumor cell-derived exosomes: A message in a bottle / Biochim Biophys Acta 1826:103~111
EL Andaloussi S / 2013 / Extracellular vesicles: biology, emerging therapeutic opportunities / Nat Rev Drug Discov 12:347~357
Johnstone RM / 1987 / Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles(exosomes) / J Biol Chem 262:9412~9420
Vlassov AV / 2012 / Exosomes : Current knowledge of their composition, biological functions, , diagnostic, therapeutic potentials / Biochim Biophys Acta 1820:940~948
Kharaziha P / 2012 / Tumor cell-derived exosomes: A message in a bottle / Biochim Biophys Acta 1826:103~111
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Immunoaffinity Characteristics of Exosomes from Breast Cancer Cells Using Surface Plasmon Resonance Spectroscopy
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