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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
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- 1 - 11 (11page)
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Malignant progression is greatly affected by dynamic cross-talk between stromal and cancer cells. Exosomes are secreted nanovesicles that have key roles in cell–cell communication by transferring nucleic acids and proteins to target cells and tissues.
Recently, MicroRNAs (miRs) and their delivery in exosomes have been implicated in physiological and pathological processes. Tumor-delivered miRs, interacting with stromal cells in the tumor microenvironment, modulate tumor progression, angiogenesis, metastasis and immune escape. Altered cell metabolism is one of the hallmarks of cancer. A number of different types of tumor rely on mitochondrial metabolism by triggering adaptive mechanisms to optimize their oxidative phosphorylation in relation to their substrate supply and energy demands. Exogenous exosomes can induce metabolic reprogramming by restoring the respiration of cancer cells and supress tumor growth. The exosomal miRs involved in the modulation of cancer metabolism may be potentially utilized for better diagnostics and therapy.
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참고문헌 (25)
참고문헌 신청
Amin DN / 2006 / Tumor endothelial cells express epidermal growth factor receptor(EGFR)but not ErbB3 and are responsive to EGF and to EGFR kinase inhibitors / Cancer Res 66
Cirri P / 2011 / Cancer associated fibroblasts : the dark side of the coin / Am J Cancer Res 1 : 482 ~ 497
Cirri P / 2012 / Cancer-associated-fibroblasts and tumour cells : a diabolic liaison driving cancer progression / Cancer Metastasis Rev 31 : 195 ~ 208
Deryugina EI / 2014 / Tissue-infiltrating neutrophils constitute the major in vivo source of angiogenesis-inducing MMP-9 in the tumor microenvironment / Neoplasia 16 : 771 ~
Deryugina EI / 2015 / Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature / Matrix Biol 44-46 : 94 ~ 112
Cirri P / 2011 / Cancer associated fibroblasts : the dark side of the coin / Am J Cancer Res 1 : 482 ~ 497
Cirri P / 2012 / Cancer-associated-fibroblasts and tumour cells : a diabolic liaison driving cancer progression / Cancer Metastasis Rev 31 : 195 ~ 208
Deryugina EI / 2014 / Tissue-infiltrating neutrophils constitute the major in vivo source of angiogenesis-inducing MMP-9 in the tumor microenvironment / Neoplasia 16 : 771 ~
Deryugina EI / 2015 / Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature / Matrix Biol 44-46 : 94 ~ 112
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