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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 266 - 270 (5page)
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초록· 키워드
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Over the last decade, comprehensive genome-wide sequencing studies have enabled us to find out unexpected genetic alterations of metabolism in cancer. An example is the identification of arginine missense mutations of isocitrate dehydrogenases-1 and -2 (IDH1/2) in glioma, acute myeloid leukemia (AML), chondrosarcomas, and cholangiocarcinoma. These alterations are closely associated with the production of a new stereospecific metabolite, (R)-2-hydroxyglutarate (R-2HG). A large number of follow-up studies have been performed to address the molecular mechanisms of IDH1/2 mutations underlying how these events contribute to malignant transformation. In the meanwhile, the development of selective mutant IDH1/2 chemical inhibitors is being actively pursued in the scientific community and pharmaceutical industry. The present review article briefly discusses the important findings that highlight the molecular mechanisms of IDH1/2 mutations in cancer and provides a current status for development of selective mutant IDH1/2 chemical inhibitors.
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참고문헌 (28)
참고문헌 신청
Andronesi OC / 2013 / Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate / J Clin Invest 123 : 3659 ~ 3663
Bleeker FE / 2009 / IDH1 mutations at residue p. R132(IDH1(R132))occur frequently in high-grade gliomas but not in other solid tumors / Hum Mutat 30 : 7 ~ 11
Cairns RA / 2013 / Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities / Cancer Discov 3 : 730 ~ 741
Dang L / 2009 / Cancer-associated IDH1 mutations produce 2-hydroxyglutarate / Nature 462 : 739 ~ 744
Dang L / 2010 / IDH mutations in glioma and acute myeloid leukemia / Trends Mol Med 16 : 387 ~ 397
Bleeker FE / 2009 / IDH1 mutations at residue p. R132(IDH1(R132))occur frequently in high-grade gliomas but not in other solid tumors / Hum Mutat 30 : 7 ~ 11
Cairns RA / 2013 / Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities / Cancer Discov 3 : 730 ~ 741
Dang L / 2009 / Cancer-associated IDH1 mutations produce 2-hydroxyglutarate / Nature 462 : 739 ~ 744
Dang L / 2010 / IDH mutations in glioma and acute myeloid leukemia / Trends Mol Med 16 : 387 ~ 397
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