지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives: We examined the effects of a mixed formula consisting of dried pomegranate concentrate powder (PCP) and the aqueous extracts of Eucommiae cortex (EC) and Achyranthis radix (AR) in rats with surgically induced osteoarthritis (OA).
Methods: Two weeks after OA-inducing surgery, a PCP:EC:AR 5:4:1 (g/g) combination or single formula was orally administered. Changes in body weight, knee thickness, maximum knee extension angle, bone mineral density of the knee joints, femoral and tibial articular surfaces, and compressive strength of the femoral and tibial articular cartilage (AC) were assessed, along with the prostaglandin E2 level, 5-lipoxygenase, matrix metalloproteinase (MMP)-2 and MMP-9 activity, and chondrogenic gene mRNA expression in the femoral and tibial AC with the synovial membrane (SM). In addition, the number of cleaved poly(ADP-ribose) polymerase, cyclooxygenase and tumor necrosis factor-α-immunoreactive cells in the femoral and tibial AC with SM were monitored, and the rate of cell proliferation was determined with a 5-bromo-2’-deoxyuridine uptake assay.
Results : The signs of surgically induced OA in rats were significantly inhibited by both PCP, EC and AR combined and single formulas. In particular, the combination formula-treated OA model rats showed dose-dependent, significantly increased inhibitory activity against all tested criteria compared with single formula-treated rats.
Conclusions: Taken together, our results suggest that the combination formula synergistically increased the anti-OA effects of its components through anti-inflammatory and chondrogenic activity in rats with surgically induced OA. In addition, 200, 100 and 50 mg/kg combination formula treatments showed dose-dependent inhibitory activity against all of the tested criteria.
Methods: Two weeks after OA-inducing surgery, a PCP:EC:AR 5:4:1 (g/g) combination or single formula was orally administered. Changes in body weight, knee thickness, maximum knee extension angle, bone mineral density of the knee joints, femoral and tibial articular surfaces, and compressive strength of the femoral and tibial articular cartilage (AC) were assessed, along with the prostaglandin E2 level, 5-lipoxygenase, matrix metalloproteinase (MMP)-2 and MMP-9 activity, and chondrogenic gene mRNA expression in the femoral and tibial AC with the synovial membrane (SM). In addition, the number of cleaved poly(ADP-ribose) polymerase, cyclooxygenase and tumor necrosis factor-α-immunoreactive cells in the femoral and tibial AC with SM were monitored, and the rate of cell proliferation was determined with a 5-bromo-2’-deoxyuridine uptake assay.
Results : The signs of surgically induced OA in rats were significantly inhibited by both PCP, EC and AR combined and single formulas. In particular, the combination formula-treated OA model rats showed dose-dependent, significantly increased inhibitory activity against all tested criteria compared with single formula-treated rats.
Conclusions: Taken together, our results suggest that the combination formula synergistically increased the anti-OA effects of its components through anti-inflammatory and chondrogenic activity in rats with surgically induced OA. In addition, 200, 100 and 50 mg/kg combination formula treatments showed dose-dependent inhibitory activity against all of the tested criteria.
목차
Introduction
Materials and methods
Results
Discussion
Conclusion
References
참고문헌 (78)
참고문헌 신청
[학술지(정기간행물)] - Dougados M / 2001 / Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebocontrolled trial. Evaluation of the Chondromodulating Effect of Diacerein in OA of the Hip / Arthritis and rheumatism 44 (11) : 2539 ~ 2547
[학술지(정기간행물)] - Tamura T / 2001 / Rhein, an active metabolite of diacerein, suppresses the interleukin-1alpha-induced proteoglycan degradation in cultured rabbit articular chondrocytes / Japanese journal of pharmacology 85 (1) : 101 ~ 104
[학술지(정기간행물)] - Krabbe KS / 2004 / Inflammatory mediators in the elderly / Experimental gerontology 39 (5) : 687 ~ 699
[학술지(정기간행물)] - Cesari M / 2004 / Inflammatory markers and physical performance in older persons : the InCHIANTI study / The journals of gerontology Series A, Biological sciences and medical sciences 59 (3) : 242 ~ 248
[학술지(정기간행물)] - Morrisette-Thomas V / 2014 / Inflamm-aging does not simply reflect increases in pro-inflammatory markers / Mechanisms of ageing and development 139 : 49 ~ 57
[학술지(정기간행물)] - Tamura T / 2001 / Rhein, an active metabolite of diacerein, suppresses the interleukin-1alpha-induced proteoglycan degradation in cultured rabbit articular chondrocytes / Japanese journal of pharmacology 85 (1) : 101 ~ 104
[학술지(정기간행물)] - Krabbe KS / 2004 / Inflammatory mediators in the elderly / Experimental gerontology 39 (5) : 687 ~ 699
[학술지(정기간행물)] - Cesari M / 2004 / Inflammatory markers and physical performance in older persons : the InCHIANTI study / The journals of gerontology Series A, Biological sciences and medical sciences 59 (3) : 242 ~ 248
[학술지(정기간행물)] - Morrisette-Thomas V / 2014 / Inflamm-aging does not simply reflect increases in pro-inflammatory markers / Mechanisms of ageing and development 139 : 49 ~ 57
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UCI(KEPA) : I410-ECN-0101-2019-519-000328700