지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 110 - 119 (10page)
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초록· 키워드
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Background: Trimethoprim/sufamethoxazole (TMP/SMX) is the recommended treatment for Pneumocystis jirovecii pneumonia (PCP). However, the efficacy and the safety of alternative salvage treatments are less guarauteed especially when patient experiences treatment failure and/or an adverse drug reactions (ADR). The purpose of this study is to recognize potential risk factors imitating successful treatment with TMP/SMX among PCP patients. Materials and Methods: Ninety one adult patients diagnosed with PCP were included after searching electronical medical records from January 2013 through July 2015 at Asan Medical Center Seoul, Korea. We compared clinical characteristics and laboratory findings including bronchoalveolar lavage (BAL) fluid analysis in patients who experienced TMP/SMX treatment failure or ADR (the case group) versus those who did not (the control group). Results: Among the enrolled PCP patients, 39 (42.9%) required salvage treatment owing to either treatment failure (28, 28.6%) and/or ADR (17, 18.7%). The BAL lymphocyte percentage (25% [IQR, 8–40%] vs. 47% [IQR, 15–62%]; P = 0.005) was lower in the case group. Diabetes mellitus (adjusted odds ratio [aOR] 4.98, 95% confidence interval [95% CI] 1.20–18.58), glomerular filtration rate ≤50 mL/min (aOR 4.48, 95% CI 1.08–18.66), and BAL lymphocyte percentage ≤45% (aOR 9.25, 95% CI 2.47–34.58) were independently associated with the case group in multivariate analysis. Conclusion: This study suggests that BAL lymphocyte count may play some role during PCP treatment. Further studies should be followed to reveal what the role of BAL lymphocyte is in the PCP treatment.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Catherinot E / 2010 / Pneumocystis jirovecii pneumonia / Infect Dis Clin North Am 24:107~138
Fillatre P / 2014 / Incidence of Pneumocystis jiroveci pneumonia among groups at risk in HIV-negative patients / Am J Med 127:1242.e11~1242.e17
Smego RA Jr / 2001 / A meta-analysis of salvage therapy for pneumocystis carinii pneumonia / Arch Intern Med 161:1529~1533
Kim T / 2012 / Outcomes of non-HIV-infected patients with Pneumocystis pneumonia and concomitant pulmonary cytomegalovirus infection / Scand J Infect Dis 44:670~677
Roblot F / 2002 / Analysis of underlying diseases and prognosis factors associated with Pneumocystis carinii pneumonia in immunocompromised HIV-negative patients / Eur J Clin Microbiol Infect Dis 21:523~531
Fillatre P / 2014 / Incidence of Pneumocystis jiroveci pneumonia among groups at risk in HIV-negative patients / Am J Med 127:1242.e11~1242.e17
Smego RA Jr / 2001 / A meta-analysis of salvage therapy for pneumocystis carinii pneumonia / Arch Intern Med 161:1529~1533
Kim T / 2012 / Outcomes of non-HIV-infected patients with Pneumocystis pneumonia and concomitant pulmonary cytomegalovirus infection / Scand J Infect Dis 44:670~677
Roblot F / 2002 / Analysis of underlying diseases and prognosis factors associated with Pneumocystis carinii pneumonia in immunocompromised HIV-negative patients / Eur J Clin Microbiol Infect Dis 21:523~531
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