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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 47 - 52 (6page)
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Pneumocystis pneumonia (PCP) is a rare disease in healthy people but a potentially fatal opportunistic infection by Pneumocystis jirovecii in immunocompromised patients with organ transplantation. We present three cases of PCP after kidney transplantation in pediatric patients. First case was a 4-year-old boy diagnosed with Denys-Drash syndrome and received living-donor kidney transplantation from his mother at age of 1. Second case was a 19-year-old male, with polycystic kidney disease, who received kidney transplantation from his mother at the age of 18. Third case was a 19-year-old female with chronic kidney disease of unknown etiology, who received kidney transplantation from her father at age of 15. These three patients who were on immunosuppressive therapy and completed of routine PCP prophylaxis for 6 months had presented with cough and dyspnea more than 1 year after transplantation. Chest x-ray all showed diffuse haziness of both lung fields, and bronchoalveolar lavage from bronchoscopy revealed Pneumocystis jirovecii infection. All patients showed clinical resolution with intravenous trimethoprim-sulfamethoxazole (TMP-SMX) therapy for at least 3 weeks and had continued secondary prophylaxis for another 6–12 months. This report suggests that clinicians should have suspicion for the possibilities of opportunistic infection such as PCP after kidney transplantation in children.
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참고문헌 (16)
참고문헌 신청
Fine RN / 2010 / What have 20 years of data from the North American Pediatric Renal Transplant Cooperative Study taught us about growth following renal transplantation in infants, children, and adolescents with end-stage renal disease? / Pediatr Nephrol 25:739~746
Neff RT / 2009 / Analysis of USRDS : incidence and risk factors for Pneumocystis jiroveci pneumonia / Transplantation 88:135~141
Arichi N / 2009 / Cluster outbreak of Pneumocystis pneumonia among kidney transplant patients within a single center / Transplant Proc 41:170~172
Rodriguez M / 2004 / Prevention of infection due to Pneumocystis spp. in human immunodeficiency virus-negative immunocompromised patients / Clin Microbiol Rev 17:770~782
Perez-Ordono L / 2014 / Late-onset Pneumocystis jiroveci i pneumonia in solid organ transplant recipients / Transpl Infect Dis 16:324~328
Neff RT / 2009 / Analysis of USRDS : incidence and risk factors for Pneumocystis jiroveci pneumonia / Transplantation 88:135~141
Arichi N / 2009 / Cluster outbreak of Pneumocystis pneumonia among kidney transplant patients within a single center / Transplant Proc 41:170~172
Rodriguez M / 2004 / Prevention of infection due to Pneumocystis spp. in human immunodeficiency virus-negative immunocompromised patients / Clin Microbiol Rev 17:770~782
Perez-Ordono L / 2014 / Late-onset Pneumocystis jiroveci i pneumonia in solid organ transplant recipients / Transpl Infect Dis 16:324~328
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