지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 123 - 147 (25page)
이용수
초록· 키워드
오류제보하기
Objectives
This study is to investigate how dose Ikhwang-San can be effective on SD rats which deteriorated immunity caused by methotrexate.
Methods
The test sample were dosed once a day for 14 days by gastric gavage at the beginning of dosage 1000, 500 and 250㎎/㎏/10㎖ from 2 days after last MTX-dosing, and the changes of the body and spleen weight, total number of blood leukocytes , total number of lymphocytes, the percentage of B-cell, T-cell, CD3+CD4+ T-cell, CD3+CD8+ T-cell and CD4+/CD8+ T-cell ratios in the blood and spleen were observed.
Results
The changes of the body and spleen weight, the total number of blood leukocytes, the total number of lymphocyte in the blood and spleen were significantly increased in IHS Extracts groups comparing with the control group. The percentage of B-cell, T-cell, CD3+CD4+ T-cell in the blood and spleen were significantly increase in IHS groups and comparing with the control group. The ratio of CD4+/CD8+ T-cell in blood and spleen was significantly increased in IHS Extracts groups comparing with the control group.
Conclusions
According to those results, Ikhwang-San has good immunostimulating effect on SD rats which had deteriorated immunity caused by methotrexate.
목차
등록된 정보가 없습니다.
참고문헌 (45)
참고문헌 신청
Abbas / 2002 / 세포분자면역학 / 범문사 : 3 ~ 38
Artym J / 2004 / Effect of lactoferrin on the methotrexate-induced sup pression of the cellular and humoral immune response in mice / Anticancer Res 24 (6) : 3831 ~ 3836
Chiappelli F / 1991 / Pituitary-Adrenal Immune system in normal subject and in patients with anorexia nervosa:The number of circulating helper T lymphocytes(CD4+) expressing
Hofman B / 1996 / Buspirone, a serotonin receptor agonist,increases CD4+ T-cell counts and modulates the immune system in HIV-seropositive subjects / AIDS 10 (12) : 1339 ~ 1
Jacqueline Sharon / 1995 / Basic Immunology / Williams & Wilkins
Artym J / 2004 / Effect of lactoferrin on the methotrexate-induced sup pression of the cellular and humoral immune response in mice / Anticancer Res 24 (6) : 3831 ~ 3836
Chiappelli F / 1991 / Pituitary-Adrenal Immune system in normal subject and in patients with anorexia nervosa:The number of circulating helper T lymphocytes(CD4+) expressing
Hofman B / 1996 / Buspirone, a serotonin receptor agonist,increases CD4+ T-cell counts and modulates the immune system in HIV-seropositive subjects / AIDS 10 (12) : 1339 ~ 1
Jacqueline Sharon / 1995 / Basic Immunology / Williams & Wilkins
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