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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2001.6
- 수록면
- 115 - 121 (7page)
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초록· 키워드
오류제보하기
Some of endocrine disruptors with sexual hormone-like effects have been increasingly reported to be immunotoxic in many species in recent several years. Phthalate esters have possible effects on the endocrine system. Prenatal exposure to di(n-butyl) phthalate (DBP) has been reported to impair the androgen-dependent development of the male reproductive tract in rat. Therefore, the immunomodulatory effect of DBP was investigated in the developing immune system of fetal and neonatal Sprague-Dawley rats. Timed-bred pregnant SD rats were given to the doses of 0, 250, 500, and 750 mg DBP/kgㆍbody weight/day by gavage once a day from gestational day (GD) 5 to 18. On GD19 or GD22/postnatal day one (PD1), the dams were euthanized, and the changes in organ weights and thymus phenotypes were examined their offsprings. At 750 mg DBP/kg ㆍb.w./day in maternal exposure group, GD19 fetuses showed decreases in body weight. The spleen/body weight ratios were reduced in GD19 fetuses from the dams exposed to 500 and 750 mg DBP/kgㆍb.w./day. There were no significant changes in thymus and spleen cellularities though these cellularities showed a tendency to decrease in a dose dependent way. In the DBPGD22/PDl offsprings, the body weights, the relative organ weights and the cellularities did not exhibit alteration. Additionally, the percentages of CD3+(CD4+CD8+, CD4+CD8-, CD4-CD8+, and CD4-CD8) and CD3-(CD4+CD8+, CD4+CD8-, CD4-CD8+, and CD4-CD8) thymocyte subsets were not changed in any DBP-treated group. The proliferative responses oj splenic T cells to Con A and B cells to LPS were decreased in all DBP-exposed GD22/PDl offsprings.
목차
ABSTRACT
Ⅰ. 서론
Ⅱ. 재료 및 방법
Ⅲ. 결과
Ⅳ. 고찰
감사의 말씀
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UCI(KEPA) : I410-ECN-0101-2009-513-013746120