지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background: Ischemic stroke may recur in many patients of previous ischemic events despite of taking antiplatelet drugs for secondary prevention of ischemic stroke. However, the proper laboratory test for monitoring antiplatelet therapy is not available in clinical situation. The rapid platelet function analyzers (RPFA) has been recently developed and used. The purposes of this study were to determine the frequency of aspirin resistance in patients with ischemic stroke and to identify the factors related with aspirin resistance using RPFA.
Methods: We consecutively enrolled 81 patients taking aspirin regularly for secondary prevention of ischemic stroke.
Demographic data, vascular risk factors (hypertension, diabetes, hyperlipidemia), drug history, hemoglobin and platelet count were recorded. We used the VerifyNow￠c-Aspirin (Ultegra￠c RPFA-ASA, Accumetric Inc., San Diego, CA) to measure the inhibition of platelet function by aspirin.
Results: Seven patients (8.6%) were identified as aspirin-non-responders on the platelet function test. Two patients who had taken aspirin medication prior to ischemic events showed insufficient platelet inhibition on the blood test. There was no significant difference between aspirin-responders and aspirin-non-responders concerning age, gender, hypertension, diabetes mellitus, hyperlipidemia, hemoglobin, and platelet count. The aspirin formula, dose and duration of treatment were not significantly different between the two groups.
Conclusions: Aspirin resistance in ischemic stroke patients is not uncommon. The clinical usefulness of routine platelet function tests needs to be further study.
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