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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 798 - 805 (8page)
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초록· 키워드
오류제보하기
Purpose The aim of this study was to investigate whether aspirin use can reduce the incidence of gastric cancer in patients with hypertension or type 2 diabetes.
Materials and Methods A total of 200,000 patients with hypertension or type 2 diabetes were randomly selected from the Korean National Health Insurance claim database. Of these, 3,907 patients who used 100 mg of aspirin regularly (regular aspirin users) and 7,808 patients who did not use aspirin regularly (aspirin non-users) were selected at a frequency of 1:2, matched by age, sex, comorbid illnesses (type 2 diabetes and hypertension), and observation periods. The incidence of gastric cancer in this cohort was then assessed during the observation period of 2004 to 2010.
Results In the matched cohort, the incidence rates of gastric cancer were 0.8% (31/3,907) for regular aspirin users and 1.1% (86/7,808) for aspirin non-users, but the cumulative incidence rates were not significantly different between groups (p=0.116, log-rank test). However, in multivariate analysis, regular aspirin users had a reduced risk of gastric cancer (adjusted hazard ratio [aHR], 0.71; 95% confidential interval [CI], 0.47 to 1.08; p=0.107). Duration of aspirin use showed significant association with reduction of gastric cancer risk (aHR for each year of aspirin use, 0.85; 95% CI, 0.73 to 0.99; p=0.044), particularly in patients who used aspirin for more than 3 years (aHR, 0.40; 95% CI, 0.16 to 0.98; p=0.045).
Conclusion Long-term low-dose aspirin use was associated with reduced gastric cancer risk in patients with hypertension or type 2 diabetes.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Mancia G / 2013 / 2013 ESH/ESC Guidelines for the management of arterial hypertension : the Task Force for the management of arterial hypertension of the European Society of Hypertension(ESH)and of the European Society of Cardiology(ESC) / J Hypertens 31:1281~1357
Pignone M / 2010 / Aspirin for primary prevention of cardiovascular events in people with diabetes : a position statement of the American Diabetes Association, a scientific statement of the American Heart Association, and an expert consensus document of the American College of Cardiology Foundation / Diabetes Care 33:1395~1402
Kune GA / 1988 / Colorectal cancer risk, chronic illnesses, operations, and medications : case control results from the Melbourne Colorectal Cancer Study / Cancer Res 48:4399~4404
Bosetti C / 2012 / Aspirin and cancer risk : a quantitative review to 2011 / Ann Oncol 23:1403~1415
Algra AM / 2012 / Effects of regular aspirin on longterm cancer incidence and metastasis : a systematic comparison of evidence from observational studies versus randomised trials / Lancet Oncol 13:518~527
Pignone M / 2010 / Aspirin for primary prevention of cardiovascular events in people with diabetes : a position statement of the American Diabetes Association, a scientific statement of the American Heart Association, and an expert consensus document of the American College of Cardiology Foundation / Diabetes Care 33:1395~1402
Kune GA / 1988 / Colorectal cancer risk, chronic illnesses, operations, and medications : case control results from the Melbourne Colorectal Cancer Study / Cancer Res 48:4399~4404
Bosetti C / 2012 / Aspirin and cancer risk : a quantitative review to 2011 / Ann Oncol 23:1403~1415
Algra AM / 2012 / Effects of regular aspirin on longterm cancer incidence and metastasis : a systematic comparison of evidence from observational studies versus randomised trials / Lancet Oncol 13:518~527
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