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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 142 - 148 (7page)
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초록· 키워드
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Background/Aims: Both fecal immunochemical test (FIT) and fecal calprotectin (Fcal) results are useful biomarkers for ulcerative colitis (UC). However, the situations in which each marker should be used are largely unknown. Methods: A total of 110 colonoscopy intervals of UC patients were assessed, and correlations between changes in colonoscopic findings and changes in the two aforementioned fecal markers were examined. Results: Among patients with mucosal healing (MH) and negative FIT or Fcal results at the initial colonoscopy, FIT and Fcal findings exhibited accuracies of 93% (38/41) and 79% (26/33), respectively, for predicting the results of the subsequent examination. Among the 24 patients who showed endoscopic activity at the precedent colonoscopy and MH at the subsequent examination, positive-to-negative conversion of FIT and Fcal findings at the subsequent examination was observed in 92% (12/13) and 62% (8/13) of patients, respectively. Among the 43 patients who showed endoscopic activity at both the precedent and subsequent examinations, Fcal findings reflected the change in endoscopic activity better than FIT results (r=0.59, p<0.0001 vs r=0.30, p=0.054). Conclusions: The FIT is useful for confirming MH and the occurrence of relapse. In contrast, Fcal is useful for monitoring the mucosal status of patients with active inflammation.
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참고문헌 (24)
참고문헌 신청
Podolsky DK / 2002 / Inflammatory bowel disease / N Engl J Med 347:417~429
Peyrin-Biroulet L / 2011 / Results from the 2nd Scientific Workshop of the ECCO. I: impact of mucosal healing on the course of inflammatory bowel disease / J Crohns Colitis 5:477~483
Schoepfer AM / 2009 / Ulcerative colitis: correlation of the Rachmilewitz endoscopic activity index with fecal calprotectin, clinical activity, C-reactive protein, and blood leukocytes / Inflamm Bowel Dis 15:1851~1858
D'Haens G / 2012 / Fecal calprotectin is a surrogate marker for endoscopic lesions in inflammatory bowel disease / Inflamm Bowel Dis 18:2218~2224
Nakarai A / 2013 / Evaluation of mucosal healing of ulcerative colitis by a quantitative fecal immunochemical test / Am J Gastroenterol 108:83~89
Peyrin-Biroulet L / 2011 / Results from the 2nd Scientific Workshop of the ECCO. I: impact of mucosal healing on the course of inflammatory bowel disease / J Crohns Colitis 5:477~483
Schoepfer AM / 2009 / Ulcerative colitis: correlation of the Rachmilewitz endoscopic activity index with fecal calprotectin, clinical activity, C-reactive protein, and blood leukocytes / Inflamm Bowel Dis 15:1851~1858
D'Haens G / 2012 / Fecal calprotectin is a surrogate marker for endoscopic lesions in inflammatory bowel disease / Inflamm Bowel Dis 18:2218~2224
Nakarai A / 2013 / Evaluation of mucosal healing of ulcerative colitis by a quantitative fecal immunochemical test / Am J Gastroenterol 108:83~89
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