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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 636 - 640 (5page)
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초록· 키워드
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Background/Aims: The diagnostic yield of fecal leukocyte and stool cultures is unsatisfactory in patients with acute diarrhea. This study was performed to evaluate the clinical significance of the fecal lactoferrin test and fecal multiplex polymerase chain reaction (PCR) in patients with acute diarrhea. Methods: Clinical parameters and laboratory findings, including fecal leukocytes, fecal lactoferrin, stool cultures and stool multiplex PCR for bacteria and viruses, were evaluated prospectively for patients who were hospitalized due to acute diarrhea. Results: A total of 54 patients were included (male, 23; median age, 42.5 years). Fecal leukocytes and fecal lactoferrin were positive in 33 (61.1%) and 14 (25.4%) patients, respectively. Among the 31 patients who were available for fecal pathogen evaluation, fecal multiplex PCR detected bacterial pathogens in 21 patients, whereas conventional stool cultures were positive in only one patient (67.7% vs 3.2%, p=0.000). Positive fecal lactoferrin was associated with presence of moderate to severe dehydration and detection of bacterial pathogens by multiplex PCR (21.4% vs 2.5%, p=0.049; 100% vs 56.5%, p=0.032, respectively). Conclusions: Fecal lactoferrin is a useful marker for more severe dehydration and bacterial etiology in patients with acute diarrhea. Fecal multiplex PCR can detect more causative organisms than conventional stool cultures in patients with acute diarrhea.
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참고문헌 (18)
참고문헌 신청
Chen CC / 2011 / Usefulness of fecal lactoferrin in predicting and monitoring the clinical severity of infectious diarrhea / World J Gastroenterol 17 : 4218 ~ 4224
Choi SW / 1996 / To culture or not to culture: fecal lactoferrin screening for inflammatory bacterial diarrhea / J Clin Microbiol 34 : 928 ~ 932
Coupland LJ / 2013 / Simultaneous detection of viral and bacterial enteric pathogens using the Seeplexⓡ Diarrhea ACE detection system / Epidemiol Infect 141 : 2111 ~ 2121
Dryden MS / 1996 / Empirical treatment of severe acute community-acquired gastroenteritis with ciprofloxacin / Clin Infect Dis 22 : 1019 ~ 1025
Gisbert JP / 2009 / Questions and answers on the role of fecal lactoferrin as a biological marker in inflammatory bowel disease / Inflamm Bowel Dis 15 : 1746 ~ 1754
Choi SW / 1996 / To culture or not to culture: fecal lactoferrin screening for inflammatory bacterial diarrhea / J Clin Microbiol 34 : 928 ~ 932
Coupland LJ / 2013 / Simultaneous detection of viral and bacterial enteric pathogens using the Seeplexⓡ Diarrhea ACE detection system / Epidemiol Infect 141 : 2111 ~ 2121
Dryden MS / 1996 / Empirical treatment of severe acute community-acquired gastroenteritis with ciprofloxacin / Clin Infect Dis 22 : 1019 ~ 1025
Gisbert JP / 2009 / Questions and answers on the role of fecal lactoferrin as a biological marker in inflammatory bowel disease / Inflamm Bowel Dis 15 : 1746 ~ 1754
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