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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 532 - 541 (10page)
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초록· 키워드
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Background/Aims: Magnifying endoscopy with narrow band imaging (ME-NBI) is a useful modality for the detailed visualization of microsurface (MS) and microvascular (MV) structures in the gastrointestinal tract. This study aimed to determine whether the MS and MV patterns in ME-NBI differ according to the histologic type, invasion depth, and mucin phenotype of early gastric cancers (EGCs). Methods: The MS and MV patterns of 160 lesions in 160 patients with EGC who underwent ME-NBI before endoscopic or surgical resection were prospectively collected and analyzed. EGCs were categorized as either differentiated or undifferentiated and as either mucosal or submucosal, and their mucin phenotypes were determined via immunohistochemistry of the tumor specimens. Results: Differentiated tumors mainly displayed an oval and/or tubular MS pattern and a fine network or loop MV pattern, whereas undifferentiated tumors mainly displayed an absent MS pattern and a corkscrew MV pattern.
The destructive MS pattern was associated with submucosal invasion, and this association was more prominent in the differentiated tumors than in the undifferentiated tumors.
MUC5AC expression was increased in lesions with either a papillary or absent MS pattern and a corkscrew MV pattern, whereas MUC6 expression was increased in lesions with a papillary MS pattern and a loop MV pattern. CD10 expression was more frequent in lesions with a fine network MV pattern. Conclusions: ME-NBI can be useful for predicting the histopathology and mucin phenotype of EGCs.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Yao K / 2002 / Novel magnified endoscopic findings of microvascular architecture in intramucosal gastric cancer / Gastrointest Endosc 56:279~284
Yokoyama A / 2010 / Novel narrow-band imaging magnifying endoscopic classification for early gastric cancer / Dig Liver Dis 42:704~708
Yagi K / 2008 / Magnifying endoscopy with narrow band imaging for early differentiated gastric adenocarcinoma / Dig Endosc 20:115~122
Nakayoshi T / 2004 / Magnifying endoscopy combined with narrow band imaging system for early gastric cancer: correlation of vascular pattern with histopathology (including video) / Endoscopy 36:1080~1084
Yoshida T / 2004 / Narrow-band imaging system with magnifying endoscopy for superficial esophageal lesions / Gastrointest Endosc 59:288~295
Yokoyama A / 2010 / Novel narrow-band imaging magnifying endoscopic classification for early gastric cancer / Dig Liver Dis 42:704~708
Yagi K / 2008 / Magnifying endoscopy with narrow band imaging for early differentiated gastric adenocarcinoma / Dig Endosc 20:115~122
Nakayoshi T / 2004 / Magnifying endoscopy combined with narrow band imaging system for early gastric cancer: correlation of vascular pattern with histopathology (including video) / Endoscopy 36:1080~1084
Yoshida T / 2004 / Narrow-band imaging system with magnifying endoscopy for superficial esophageal lesions / Gastrointest Endosc 59:288~295
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